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Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin,a synthetic analogue of the tripeptide hemiasterlin

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摘要AIM:To investigate the inhibitory effects of taltobulin (HTI-286),a synthetic analogue of natural hemiasterlin derived from marine sponges, on hepatic tumor growth in vitro andin vivo.METHODS: The potential anti-proliferative effects of HTI-286 on different hepatic tumor cell lines in vitro and in vivo were examined.RESULTS:HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L± 1 nmol/L)in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure. Moreover, intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allogratt model).CONCLUSION:HTI-286 might be considered a potent promising drug in treatment of liver malignancies.HTI-286 is currently undergoing clinical evaluation in cancer patients.

作者单位 Department of General,Visceral and Thoracic Surgery,University Medical Center Hamburg-Eppendorf,Hamburg,Germany;Department of Visceral and Transplantation Surgery,University Clinic Bern,Switzerland ^[1] Department of Clinical Research, University of Bern, Switzerland ^[2] Institute of Clinical Radiology, University of Bern, Switzerland ^[3] Gastrozentmm Hirslanden-Viszeralchirurgie,Hirslanden Klinik Zurich, Switzerland, Department of Visceral and Transplantation Surgery and Department of Clinical Research,University of Bern, Switzerland ^[4]

关键词 Hepatocellular carcinoma Antimicrotubule agent HTI-286

分类号 R3（基础医学）

栏目名称

LIVER CANCER

发布时间 2006-12-18（万方平台首次上网日期，不代表论文的发表时间）

基金项目

Grants of the Professor M Cloetta Foundation and Onco Swiss（(SKL1221-02-2002)）

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