摘要目的 探讨血药浓度监测联合护理干预对肺移植患者服药依从性的影响.方法 将2011年4月-2013年12月46例肺移植患者按手术次序分为研究组和对照组各23例,对照组接受常规护理,研究组在此基础上接受以血药浓度监测结果为依据的护理干预.结果 手术6个月后两组患者服药依从性比较差异无统计学意义(P＞0.05),12个月后研究组患者服药依从21例(91.30％),对照组18例(78.26％),差异有统计学意义(x2 =8.641,P＜0.05).用药后6个月两组患者血药浓度比较,差异无统计学意义(P＞0.05).用药后12个月研究组患者的血药浓度为(13.15±3.14) ng/L,高于对照组,差异有统计学意义(t =7.658,P＜0.05).结论 护理干预能切实提高肺移植患者服药依从性.建立良好的护患关系、强化健康教育、反复训练、密切观察患者药物血浓度与病情变化是确保护理干预提高肺移植患者服药依从性的关键.

abstractsObjective To investigate impact of nursing intervention on medication compliance in lung transplant patients.Methods A total of 46 lung transplant patients from April 2011 to December 2013 were divided into the experimental group(n =23) and the control group (n =23) by operation order.The control group received routine care,while on the basis of it,the experimental group received nursing intervention based on the result of blood concentration.Results The medication adherence after 6 months of the operation between the two groups had no significant differences (P ＞0.05).After 12 months of intervention,21 patients (91.30％) in the experimental group complied with the medication,18 patients (78.26％) in the control group complied with the medication.There was significant difference between the two groups (x2 =8.641,P ＜ 0.05).The blood concentrations after 6 months of the operation between the two groups had no significant differences (P ＞ 0.05).After 12 months,the blood concentrations of the experimental group was (13.15 ± 3.14) ng/L,which was significantly higher than that of the control group (t =7.658,P ＜ 0.05).Conclusions Nursing intervention can effectively improve medication compliance of lung transplant patients.Establishing a good nurse-patient relationship,strengthening health education,doing repeated training and condition changes of patients is the key point to improve medication compliance of lung transplant patients.