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目的：探讨综合护理应用于重症胰腺炎维持性血液透析治疗患者的心理应激状态以及生活质量的影响。方法选取2011年1月—2013年1月哈尔滨医科大学附属第一医院收治的90例重症胰腺炎患者，将其随机分为观察组以及对照组，对照组采用常规护理模式，观察组采用综合护理，应用汉密尔顿焦虑量表(HAMA)以及简明健康状况问卷(SF-36)分别对两组患者护理前后的心理状态以及生活质量进行评价。结果干预后两组HAMA评分均较治疗前明显改善，但是观察组改善程度更加明显(P<0.05)，生活质量评分方面干预后对照组与干预前比较差异无统计学意义(P>0.05)，观察组均较治疗前明显改善，组间比较差异有统计学意义(P<0.05)。结论采用综合护理模式对重症胰腺炎持续性血液透析治疗患者进行护理可以显著改善患者的精神状态以及生活质量，促进身体机能的恢复，提高疗效。

Objective To explore the effects of comprehensive nursing on the psychological stress state and quality of life in patients with severe acute pancreatitis. Methods A total of 90 severe acute pancreatitis patients in the First Affiliated Hospital of Harbin Medical University from January 2011 to January 2013 were randomly admitted to either observation group or control group. The patients of control group adopted routine care model and the patients of observation group received integrated care. The mental state and quality of life of the two groups were evaluated by the Hamilton Anxiety Scale ( HAMA ) and the concise Health Questionnaire (SF-36). Results After the intervention, two groups of HAMA scale score was significantly improved compared with before treatment, but the degree of the observation group′s improvement was more obvious(P <0. 05). Before and after the intervention, there was no significant difference in the quality of life of the control group (P>0. 05). The patients of observation group was significantly improved than before treatment,the difference between the two groups was statistically significant ( P < 0. 05 ). Conclusions The implementation of comprehensive nursing can improve in the mental state and quality of life of patients with severe acute pancreatitis treated by comprehensive nursing mode, and promote the recovery of physical function and improve the curative effect.