摘要目的 探讨乳腺专用伽玛显像(BSGI)、钼靶成像、超声及联合检查对乳腺癌的诊断价值.方法 回顾性分析2012年3月至2013年1月于本院就诊的95例乳腺肿块患者的临床资料,所有患者均接受手术治疗,收集术前BSGI、钼靶成像和超声检查结果并与术后病理结果进行比较,分析不同检查方法诊断乳腺癌的灵敏度、特异度、准确度、阳性预测值和阴性预测值.结果 95例患者术后病理诊断为乳腺癌63例(67个病灶)及乳腺良性病变32例(40个病灶).BSGI、钼靶成像、超声、BSGI+钼靶成像联合检查、BSGI+超声联合检查、钼靶成像+超声联合检查诊断乳腺癌的灵敏度分别为95.2％(60/63)、82.5％(52/63)、93.7％(59/63)、77.8％(49/63)、90.5％(57/63)及77.8％ (49/63),特异度分别为75.0％(24/32)、75.0％(24/32)、65.6％(21/32)、87.5％ (28/32)、84.4％(27/32)及84.4％ (27/32),准确度分另为88.4％ (84/95)、80.0％ (76/95)、84.2％ (80/95)、81.1％(77/95)、88.4％ (84/95)及80.0％(76/95),阳性预测值分别为88.2％(60/68)、86.7％(52/60)、84.3％(59/70)、92.5％(49/53)、91.9％(57/62)及90.7％ (49/54),阴性预测值分别为88.9％ (24/27)、68.6％ (24/35)、84.0％ (21/25)、66.7％ (28/42)、81.8％(27/33)及65.9％ (27/41).BSGI与超声检查检出7例钼靶成像漏诊的乳腺组织呈致密型的乳腺癌.结论 BSGI对于乳腺癌的诊断具有一定的临床应用价值,是钼靶成像和超声检查的有效补充.

abstractsObjective To investigate the diagnostic value of breast specific gamma imaging (BSGI),mammography (MMG),ultrasonography (US) and combined examination for the diagnosis of breast cancer.Methods The clinical data of 95 patients with breast tumor hospitalized in our hospital between March 2012 and January 2013 were retrospectively analyzed.All the patients underwent surgery.The BSGI,MMG and US findings before the operation were collected,and compared with the pathological findings after the operation.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of different examination methods for the diagnosis of breast cancer were evaluated.Results In 95 patients,63 were diagnosed with breast cancer (67 lesions) and 32 were diagnosed with benign breast lesions (40 lesions) by pathology after the operation.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of BSGI,MMG,US,BSGI+MMG,BSGI+US,MMG+US were [95.2％ (60/63),82.5％ (52/63),93.7％ (59/63),77.8％ (49/63),90.5％ (57/63) and 77.8％ (49/63)],[75.0％ (24/32),75.0％ (24/32),65.6％ (21/32),87.5％ (28/32),84.4％ (27/32) and 84.4％ (27/32)],[88.4％ (84/95),80.0％ (76/95),84.2％ (80/95),81.1％ (77/95),88.4％ (84/95) and 80.0％ (76/95)],[88.2％ (60/68),86.7％ (52/60),84.3％(59/70),92.5％ (49/ 53),91.9％ (57/62) and 90.7％ (49/54)],and [88.9％ (24/27),68.6％ (24/35),84.0％ (21/25),66.7％ (28/42),81.8％ (27/33) and 65.9％ (27/41)],respectively.Seven breast tissues with dense breast cancer were missed by MMG but were determined by BSGI and US.Conclusion BSGI shows certain clinical value for the diagnosis of breast cancer,effectively supporting MMG and US.