摘要目的 探讨广州地区男性前列腺增生症(BPH)患者中,代谢综合征各参数与前列腺体积、年增长率之间的关系.方法 收集2005年1月至2011年12月本院完成国际前列腺症状评分(IPSS)问卷、直肠指检(DRE)、前列腺超声检查和人体测量(包括身高、体质量、血压)的139例60岁以下BPH患者,根据2005年美国国家胆固醇教育计划成人治疗组第3次指南(NCEP-ATPⅢ)的标准,将患者分为代谢综合征组(104例)和非代谢综合征组(45例).监测BPH患者平均IPSS评分、排尿症状评分、储尿期症状评分、生活质量评分、最大尿流率、前列腺体积和前列腺年增长率等前列腺相关指标和身高、体质量、空腹血糖、高密度脂蛋白胆固醇、甘油三酯、体质量指数、收缩压和舒张压等代谢综合征相关临床进展参数,比较两组BPH患者前列腺相关指标和代谢综合征相关临床进展参数;应用相关分析测试代谢综合征身高、体质量、空腹血糖、高密度脂蛋白胆固醇、甘油三酯(TG)、体质量指数、收缩压和舒张压等各组分与前列腺体积和前列腺年增长率的线性关系.结果 两组BPH患者的IPSS评分、排尿症状评分、储尿期症状评分、生活质量评分、最大尿流率、前列腺体积和前列腺年增长率以及平均体质量、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、体质量指数、收缩压和舒张压之间差异有统计学意义(均P＜0.05).代谢综合征患者的年龄、体质量指数、空腹血糖、高密度脂蛋白与前列腺总体积和年增长率之间存在着相关性(前列腺总体积:r1=0.242、r2=0.264、r3=0.406、r4=-0.341,前列腺年增长率:r5=-0.424、r6=0.144、r7=0.427、r8=-0.060,均P＜0.05).结论 代谢综合征非常普遍存在于BPH患者中,并且与60岁以下的中国男性的日益增长的前列腺总体积和年增长率密切相关.

abstractsObjective To investigate the relationship among metabolic syndrome (MetS) components and prostate volume and annual prostate growth rate in Guangzhou male patients with benign prostatic hyperplasia (BPH).Methods A total of 139 BPH patients aged below 60,who completed the International Prostate Symptom Score (IPSS) questionnaire,digital rectal examination (DRE),prostate ultrasound and anthropometric measurements (including height,weight,and blood pressure) at our hospital between January 2005 to December 2011,were included in the study.According to the 2005 Guidelines of US National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP-ATP Ⅲ),patients were divided into the metabolic syndrome group (n=104) and non-metabolic syndrome group (n=45).The two groups of BPH patients were monitored and compared for prostate-related indicators such as mean IPSS score,voiding symptom,storage symptom,quality of life,maximum urinary flow rate (Qmax),prostate volume and annual prostate growth rate,as well as MetS components such as height,body weight,fasting blood glucose (FBG),total cholesterol (TC),triglycerides (TG),high-density lipoprotein cholesterol (HDL-C),body mass index (BMI),systolic and diastolic blood pressures.Linear correlations between MetS components (such as height,body weight,FBG,HDL-C,TG,BMI,systolic and diastolic blood pressures) and prostate volume and annual prostate growth rate were tested.Results The two groups of BPH patients showed statistically significant differences in IPSS score,voiding symptom score,storage symptom score,quality of life,Qmax,prostate volume and annual prostate growth rate,mean body weight,FBG,TC,TG,HDL-C,BMI,and systolic and diastolic blood pressures (all P＜0.05).In patients with MetS,the patient age,BMI,FBG and HDL-C were significantly correlated with and total prostate volume (r1=0.242,r2=0.264,r3=0.406,and r4=-0.341,all P＜0.05) and annual prostate growth rate (r5=-0.424,r6=0.144,r7=0.427,and rs=-0.060,all P＜0.05).Conclusion Metabolic syndrome is very common in patients with BPH,and is closely correlated to total prostate volume and annual prostate growth rate in Chinese males aged below 60 years.