摘要目的 探讨超声弹性成像技术(UE)联合病理液基细胞学技术(LCT)在甲状腺微小结节性病变诊断中的效果及应用价值,为甲状腺微小结节性病变的诊断提供新思路.方法 对甲状腺微小结节性病变进行UE检查及超声引导下细针穿刺LCT检查,汇总其UE评分及LCT检查结果,应用logistic回归和ROC曲线下面积(AUC)及其95%置信区间评价两种技术在甲状腺微小结节性病变精确诊断中的效果和价值.结果 以组织病理学诊断结果为金标准,以此计算出超声弹性成像联合液基细胞学的曲线下面积AUC=0.84,95% CI :0.69~0.99,诊断灵敏度为96.87%,特异度为64.64%,阳性预测值为92.86%,阴性预测值为79.02% .结论 UE联合LCT,可对甲状腺微小结节性病变的诊断具有明确意义,有广泛的推广价值.

abstractsObjective To investigate the efficacy and clinical value of ultrasound elastography (UE)combined with liquid?based cytology test(LCT)in the diagnosis of thyroid micronodular lesions,and to provide new ideas for the diagnosis of thyroid micronodular lesions. Methods UE examination and ultrasound?guided fine needle aspiration LCT were performed in 58 cases of thyroid micronodular lesions. The UE scores and LCT examination results were summarized. Logistic regression and area under the ROC curve(AUC)and its 95% confidence interval(CI)were used to evaluate the efficacy and clinical value of the two techniques in the accurate diagnosis of thyroid micronodular lesions. Results The histopathological diagnosis was used as the gold standard. Thereby,the AUC of ultrasound elastography combined with liquid?based cytology test was 0.84 (95%CI :0.69~0.99). The diagnostic sensitivity was 96.87%, and the specificity was 64.64%. The positive predictive value was 92.86%,and the negative predictive value was 79.02%. Conclusion The combination of UE and LCT is significant in the diagnosis of thyroid micronodular lesions,and it justifies widespread use.