摘要探究慢性阻塞性肺疾病（COPD）患者血清淀粉样蛋白A（SAA）、颗粒蛋白前体（PGRN）的表达及临床意义。研究发现血清SAA、PGRN在急性加重期COPD（AECOPD）中呈高表达，AECOPD患者血清SAA、PGRN水平与第1秒用力呼气容积占预计值百分比(FEV1%预计值)及预后均具有负相关性。血清SAA、PGRN水平升高是AECOPD预后不良的危险因素，检测血清SAA、PGRN有助于预测AECOPD病情及预后。

abstractsThe purpose of this study was to investigate the expression and clinical significance of serum amyloid A (SAA) and progranulin (PGRN) in patients with chronic obstructive pulmonary disease (COPD) . The study found that serum SAA and PGRN were highly expressed during acute exacerbation of COPD (AECOPD) . The serum SAA and PGRN levels in AECOPD patients were negatively correlated with the predicted value of forced expiratory volume in the first second (FEV1% predicted) and prognosis. Increased levels of serum SAA and PGRN are risk factors for poor prognosis of AECOPD. Detection of serum SAA and PGRN can help predict the severity and prognosis of AECOPD.