摘要目的:探讨分泌型卷曲相关蛋白5（SFRP5）、单核细胞趋化蛋白1（MCP-1）、血脂水平对急性心肌梗死（AMI）患者经皮冠状动脉介入治疗（PCI）术后近期预后的影响。方法:选取2018年1月至2021年3月西安交通大学第二附属医院收治的AMI患者140例为AMI组，同期来院体检者50例为对照组。比较AMI组和对照组血清SFRP5、MCP-1、血脂水平。根据AMI患者PCI术后主要不良心血管事件（MACE）发生情况分为MACE组和非MACE组，采用logistic回归分析AMI患者PCI术后近期预后的影响因素。采用受试者操作特征（ROC）曲线分析SFRP5、MCP-1、血脂指标对AMI患者PCI术后近期预后的评估价值。结果:对照组血清SFRP5、高密度脂蛋白胆固醇（HDL-C）水平显著高于AMI组，MCP-1水平显著低于AMI组（均 P<0.05）。AMI患者PCI术后30 d，发生MACE者27例纳入MACE组，未发生MACE者113例纳入非MACE组。MACE组血清SFRP5、HDL-C、左心室射血分数（LVEF）显著低于非MACE组，MCP-1水平显著高于非MACE组（均 P<0.05）。采用logistic回归分析显示，SFRP5、HDL-C为AMI患者PCI术后近期预后的保护因素，MCP-1为AMI患者PCI术后近期预后的危险因素（ OR=0.885、0.866、1.167，均 P<0.05）。ROC曲线显示，SFRP5、MCP-1、HDL-C评估AMI患者PCI术后近期预后的曲线下面积（AUC）值分别为0.876、0.793、0.803。 结论:SFRP5、HDL-C、MCP-1与AMI患者PCI术后近期预后明显相关，可作为近期预后评估的有效指标。

abstractsObjective:To determine the effects of secreted frizzled-related protein 5 (SFRP5) , monocyte chemoattractant protein 1 (MCP-1) , and blood lipid levels on the short-term prognosis of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) .Methods:A total of 140 AMI patients admitted to the Second Affiliated Hospital of Xi’an Jiaotong University from January 2018 to March 2021 were enrolled as the AMI group, and 50 patients who came to the hospital for physical examination during the same period were enrolled as the control group. The serum SFRP5, MCP-1 and blood lipid levels were compared between the AMI and the control groups. According to occurrence of major adverse cardiovascular events (MACE) after PCI, the AMI patients were further divided into MACE group and non-MACE group. Logistic regression was used to analyze the factors affecting the short-term prognosis of AMI patients after PCI. Receiver operating characteristic (ROC) curve was used to analyze the value of SFRP5, MCP-1 and blood lipids in evaluating the short-term prognosis of AMI patients after PCI.Results:The levels of serum SFRP5 and high-density lipoprotein-cholesterol (HDL-C) in the control group was significantly higher than those in the AMI group, and the level of MCP-1 was significantly lower than that in the AMI group (both P<0.05) . At 30 d after PCI, 27 of the AMI patients experienced MACE and were included in the MACE group, and remaining 113 without MACE were included in the non-MACE group. The levels of serum SFRP5, HDL-C, and left ventricular ejection fraction (LVEF) in the MACE group were significantly lower than those in the non-MACE group, and the level of MCP-1 was significantly higher than that in the non-MACE group (all P<0.05) . Logistic regression analyses showed that SFRP5 and HDL-C were are the protective factors, while MCP-1 is the risk factor, for the short-term prognosis of AMI patients after PCI ( OR=0.885, 0.866, 1.167, all P<0.05) . On the ROC curve, the area under curves (AUCs) of SFRP5, MCP-1 and HDL-C for short-term prognosis assessment of AMI patients after PCI were 0.876, 0.793 and 0.803, respectively. Conclusion:SFRP5, HDL-C, MCP-1 are significantly related to the short-term prognosis of AMI patients after PCI, and can be used as effective indicators for the evaluation of patients’ short-term prognosis.