摘要肛门直肠畸形(anorectal malformation，ARM)是最常见的消化道先天畸形，发病率为3.26/10 000。ARM常伴发其他系统畸形，其发病机制仍不明确。由于ARM胚胎往往难以获得，常用动物模型代替人类样本对ARM的致病机制进行研究，因此动物模型对于ARM发病机制的研究具有重要意义。ARM动物模型包括药物诱导动物模型、基因敲除动物模型以及自发性动物模型。本综述对国内外常用的ARM动物模型进行总结和比较，以期探讨各种模型的优缺点，为ARM发病机制的研究提供参考。

abstractsAnorectal malformations (ARM) represent the most prevalent congenital malformation within digestive tract, occurring in approximately 3.26 out of 10, 000 births.Notably, ARM frequently coexists with congenital malformations affecting other bodily systems.Despite a growing body of researches, the underlying mechanisms contributing to ARM pathogenesis remain largely elusive.Because of difficulties in obtaining human embryos, animal models are often employed for elucidating the pathogenesis of ARM instead of human samples.Consequently, the utilization of animal models becomes imperative in unraveling the intricate mechanisms associated with this condition.Various animal models have been established to simulate ARM, encompassing drug-induced, gene knockout and spontaneous models.This review comprehensively summarized and compared representative ARM models both domestically and internationally, focusing upon the distinctive advantages and limitations associated with each model, providing valuable insights and references for further investigations into the mechanisms underlying ARM development.