摘要目的:探讨有晶状体眼可植入式眼内镜(ICL)V4c矫治中高度近视患者术后1年前房的稳定性。方法:采用系列病例观察研究方法，对2016年3月至2017年10月在徐州市第一人民医院行ICL V4c植入术的中高度近视患者19例37眼的病例资料进行分析。患者年龄20~29岁，术前等效球镜度(SE)为-5.875~-15.750 D，平均(-9.743±3.220)D。所有术眼随访1年，观察术后术眼视力、SE和眼压变化，分别于术前及术后1个月、6个月、1年采用Pentacam眼前节分析仪测量术眼前房深度(ACD)、前房容积(ACV)和前房角度数(ACA)，并评估ICL V4c植入后不同时间点ICL拱高的变化。结果:手术前后术眼视力总体比较差异有统计学意义( F＝5.057， P＝0.007)，其中术后1年术眼裸眼视力(UCVA)优于术前最佳矫正视力(BCVA)，差异有统计学意义( P<0.05)。术前与术后1个月、6个月、1年术眼SE和眼压总体比较差异均无统计学意义( F＝1.294、1.302，均 P>0.05)。术前及术后1个月、6个月和1年术眼ACD、ACV、ACA总体比较差异均有统计学意义( F＝44.811、889.971、196.096，均 P<0.001)，其中术后1个月、6个月和1年ACD、ACV和ACA均低于术前，差异均有统计学意义(均 P<0.001)。术后1个月、6个月和1年术眼ICL拱高值分别为(484.860±183.634)、(464.351±170.167)和(433.784±168.550)μm，总体比较差异有统计学意义( F＝7.256， P＝0.001)；与术后1个月和术后6个月比较，术后1年术眼ICL拱高值明显下降，差异均有统计学意义( P＝0.006、0.041)。 结论:中高度近视眼接受ICL V4c植入术后1年前房结构稳定，UCVA优于术前BCVA，手术安全、有效。

abstractsObjective:To investigate the stability of anterior chamber following implantable collamer lens (ICL) V4c implantation for one year in moderate and high myopic eyes.Methods:An observational case series study was conducted.Medical data of 19 patients (37 eyes) who received ICL V4c implantation in Xuzhou First People's Hospital from March 2016 to October 2017 were collected.The patients were 20 to 29 years old, with the preoperative spherical equivalent (SE) of -5.875 to -15.750 D, with an average of (-9.743±3.220)D.All eyes were followed up for one year, and the changes of visual acuity, SE and intraocular pressure were observed.Pentacam anterior eye segment analyzer was used to measure the anterior chamber depth (ACD), anterior chamber volume (ACV) and anterior chamber angle (ACA) before operation and at 1 month, 6 months and 1 year after operation, and to evaluate the vaults of the ICL V4c at different time points after implantation.This study protocol adhered to the Declaration of Helsinki and was approved by an Ethics Committee of Xuzhou First People's Hospital (No.xxy11[2015]-XJS-004). Written informed consent was obtained from each subject.Results:There were statistically significant differences in visual acuity between before and after operation ( F=5.057, P=0.007), and the one-year postoperative uncorrected visual acuity (UCVA) was significantly better than the best corrected visual acuity (BCVA) before operation ( P<0.05). There were no significant differences in SE and intraocular pressure among different time points ( F=1.294, 1.302; both at P>0.05). There were significant differences in ACD, ACV and ACA among different time points ( F=44.811, 889.971, 196.096; all at P<0.001). ACD, ACV and ACA at 1 month, 6 months and 1 year after operation were significantly lower than those before operation (all at P<0.001). There was a significant difference in the 1-month, 6-month and 1-year postoperative ICL vault ( F=7.256, P=0.001). The ICL vault at 1 year after operation was (433.784±168.550)μm, which was significantly decreased in comparison with (484.860±183.634)μm at 1 month and (464.351±170.167)μm at 6 months after operation ( P=0.006, 0.041). Conclusions:The anterior chamber is stable in one year after ICL V4c implantation, and the UCVA is better than preoperative BCVA.ICL V4c is safe and effective for moderate and high myopia.