摘要1例58岁男性患者因突发胸痛行急诊冠状动脉(冠脉)造影术于前降支置入支架1枚,术后给予阿司匹林100 mg(1次/d)和氯吡格雷75 mg(1次/d)双联抗血小板药物治疗.2周后患者再次出现胸痛入院,冠脉造影示支架内血栓形成.行血栓抽吸术,同时血栓弹力图检测示氯吡格雷低反应性.增加氯吡格雷剂量至150 mg、1次/d.1个月后复查血栓弹力图,示二磷酸腺苷的抑制率在正常范围内,同时复查冠脉造影示支架内血流通畅.门诊随访3个月,患者未再出现胸闷胸痛等症状.

abstractsA 58-years-old male patient underwent stent implantation in anterior descending coronary artery in emergency angiography because of acute chest pain.After operation, aspirin 100 mg and clopidogrel 75 mg once daily were given.Two weeks later, the patient was hospitalized again due to chest pain.Coronary angiography demonstrated stent thrombosis.Thrombectomy was performed, meanwhile,thrombelastogram revealed that clopidogrel presented low reactivity.Subsequently, the daily dose of clopidogrel was adjusted to 150 mg.One month later, thrombelastogram showed adenosinediphosphate inhibition rate was within the normal range, no chest pain and other symptoms recurred at 3 months of follow-up and coronary angiography showed stent patency.