摘要1例32岁乳腺癌患者术后接受表柔比星联合环磷酰胺方案序贯紫杉醇化疗.应用紫杉醇(120 mg,1次/周静脉滴注)第1周期后第6天,患者出现双足大拇趾甲空洞,孔径约2 mm.按原方案行紫杉醇第2周期化疗.6d后,趾甲空洞变大,略有疼痛感.停用紫杉醇.给予双足保暖,并口服甲钴胺和外用红霉素软膏.4d后,患者足部疼痛感减轻,空洞未再增大.

abstractsA 32-year-old woman with breast cancer received a postoperative adjuvant chemotherapy with epirubicin plus cyclophosphamide followed by paclitaxel.The drug regimen of paclitaxel was intravenous infusion 120 mg once a week.On the day 6 after the first cycle of paclitaxel treatment, the patient developed bilateral big toenail hollowness, the aperture was about 2 mm.She was given the second cycle of paclitaxel according to the original plan.Six days later, the hollow toenail was worsened with slight pain.Paclitaxel was stopped.Mecobalamin, erythromycin ointment and keeping warm of feet were applied.Four days later,the pain was reduced, and the toenail hollowness did not continue to enlarge.