摘要1例29岁男性患者因溃疡性结肠炎接受左氧氟沙星等治疗，因疗效不佳，给予英夫利西单抗300 mg静脉滴注，用药3次后病情平稳。1个月后患者再次出现黏液脓血便，肠镜检查示溃疡性结肠炎（活动期），予以英夫利西单抗300 mg静脉滴注1次+硫唑嘌呤50 mg/d口服、1次/d。23 d后，患者出现上腹部持续性疼痛，血清淀粉酶411 U/L，血清脂肪酶1 415 U/L，血清胰淀粉酶374 U/L；腹部CT提示急性胰腺炎，考虑与硫唑嘌呤有关。停用硫唑嘌呤并予禁食、抑酸、抗感染、抑制胰液分泌等治疗，7 d后患者症状缓解，血淀粉酶及脂肪酶恢复正常。1个月后患者再次按原剂量自行口服硫唑嘌呤，6 h后急性胰腺炎症状复现，血清淀粉酶1 408 U/L。停用该药并给予上述治疗，5 d后患者症状缓解，复查血常规及血清淀粉酶恢复正常。

abstractsA 29-year-old male patient was treated with levofloxacin and other treatments for ulcerative colitis. Due to poor curative effect, he was given infliximab 300 mg intravenously, and his condition was stable after 3 times of medication. One month later, the patient developed mucinous bloody stool again, and enteroscopy showed ulcerative colitis (active phase). The patient received infliximab 300 mg intravenously once every 8 weeks and azathioprine 50 mg once daily orally. After 23 days of treatment, the patient developed persistent pain in the upper abdomen, serum amylase was 411 U/L, blood lipase was 1 415 U/L, and serum pancreatic amylase was 374 U/L. Abdominal CT showed acute pancreatitis, which was considered to be related to azathioprine. Seven days after discontinuation of azathioprine and treatment with fasting, acid suppression, anti-infection, and pancreatic secretion inhibition, his symptoms were relieved, and serum amylase and lipase levels returned to normal. One month later, the patient took azathioprine orally again according to the original dose by himself, and the symptoms of acute pancreatitis reappeared 6 hours later. The drug was stopped and the above treatments were given. Five days later, the patient′s symptoms were relieved, and the blood routine examination and serum amylase returned to normal.