摘要目的 分析最近两年浙南地区角膜外伤后真菌性角膜炎患者的病原分布及其特点.方法 收集2013年1月至2014年12月123例真菌性角膜炎病例.对真菌培养的阳性率、菌株分布、季节分布、患者来源、性别分布、职业及病因进行回顾性分析总结.结果 123例标本中有90例真菌培养阳性,检出率为73.2％.其中最常见的致病菌为镰刀菌,检出菌株44例(占48.9％),霉菌检出17例(占18.9％),链隔孢属检出11例(占12.2％),酵母菌检出10例(占11.1％),青霉菌检出6例(占6.7％),丝状真菌(未定型)检出2例(占2.2％).职业分布:农民82例(占66.7％),城镇居民13例(占10.6％),郊区务工人员10例(占8.1％),养殖户8例(占6.5％),其他从业人员10例(占8.1％).季节分布特点:下半年前来就诊的真菌性角膜炎患者明显多于上半年者.病因分布:自述有角膜擦伤史者96例、异物溅入眼20例及化学伤7例.结论 镰刀菌是浙南地区真菌性角膜炎的主要致病菌,霉菌次之.农民是真菌性角膜炎的易感人群,下半年是浙南地区真菌性角膜炎的高发时段,外伤是真菌性角膜炎最常见的诱发因素[1].

abstractsObjective To analyze the pathogen distribution and characteristics of traumatic fungal keratitis in south Zhejiang in last two years.Methods One hundred and twenty-three cases with fungal keratitis from January 2013 to December 2014 were collected.The positive rate of fungal culture, strain distribution, seasonal distribution, sources of patients, gender distribution, profession, and etiology were retrospectively analysed.Results Among the 123 cases, the number of positive culture was 90 and the positive rate was 73.2％.The main pathogenic bacterium was Fusarium which was detected in 44 cases (48.9％), the next was Aspergillums which was detected in 17 cases (18.9％), 11 cases (12.2％) were Alternaria, 10 cases (11.1％) were Candida, 6 cases (6.7％) were Penicillium and 2 case (2.2％) were Filamentous fungi (undifferentiated).Profession distribution: About 82 cases (67％) were farmer, 13 cases (10.6％) were urban residents, 10 cases (8.1％) were rural migrant workers, 8 cases (6.5％) were culturist and 10 cases (8.1％) were other professions.Seasonal distribution: The number of the fungal keratitis patients in the second half of the year was significantly more than that in the first half of the year.Etiology distribution: 96 patients had history of coneal abrasion, 20 cases were caused by foreign bodies splashing, 7 cases were chemical injury and 28 cases were caused by other reasons.Conclusion The Fusarium is the predominant pathogen of ocular fungal infection in the south of Zhejiang followed by Aspergillums.Farmers are susceptible to fungal keratitis.The second half of the year is the peak time of fungal keratitis.And trauma is the most common inducing factor of fungal keratitis[1].