摘要目的 评价血清降钙素原(PCT)水平对胰十二指肠切除术(PD)术后并发症发生的预测价值.方法 收集2016年3月1日至12月31日间第二军医大学长海医院胰腺外科择期行PD的87例患者的临床资料,记录患者的一般及术后情况,检测术前及术后1、3、5 d血清PCT水平及白细胞(WBC)计数,绘制受试者工作特征(ROC)曲线,计算ROC曲线下面积(AUC),确定截断值,计算诊断敏感性及特异性.按是否出现并发症分为并发症组(42例)与无并发症组(45例),比较两组间各项指标是否存在差异.结果 并发症组与无并发症组患者的年龄、性别、是否存在糖尿病、有无梗阻性黄疸、各项实验室检查指标(包括PCT)、手术时间、术中出血量、肿瘤性质的差异均无统计学意义,具有可比性;但并发症组患者住院天数显著长于无并发症组,差异有统计学意义(24 d比15 d,P<0.001).42例并发症组患者PD术后发生胰瘘18例次、腹腔感染13例次、胃排空障碍7例次、出血8例次、胆瘘2例次、切口感染2例次.发生胃排空障碍、出血、胆瘘及切口感染患者术后血清PCT水平与无并发症组患者的差异无统计学意义(P值均>0.05),但18例胰瘘患者术后3、5 d,13例腹腔感染患者术后1、3、5 d血清PCT水平均显著高于无并发症组,差异有统计学意义(P值均<0.05).术后3、5 d血清PCT联合WBC预测术后胰瘘的敏感性(88.9%,72.7%)、特异性(68.5%,78.2%),预测腹腔感染的敏感性(100%,100%)、特异性(45.9%、44.4%)均优于单用PCT或WBC.结论 血清PCT水平可以较好地预测PD术后患者的腹腔感染及胰瘘,PCT联合WBC检测预测胰瘘与腹腔感染的价值更高.

abstractsObjective To investigate the utility of plasma procalcitonin (PCT) as an early predictor for postoperative complications in patients who underwent elective pancreaticoduodenectomy (PD).Methods Clinical data of 87 patients who underwent elective PD in Changhai Hospital from March.1, 2016 to Dec.31, 2016 were collected.The general data, postoperative recovery, serum PCT level and white blood cell (WBC) count before, 1 d, 3 d and 5 d after PD were recorded.ROC curve was drawn and AUC was calculated to determine the cutoff value, sensitivity and specificity.Patients were divided into complication group (n=42) and noncomplication group (n=45) based on the occurrence of post-operative complications, and the comparisons between the two groups were performed.Results There were no significant differences on the age, gender, diabetes, obstructive jaundice, laboratory tests including PCT, operative time, blood loss volume during surgery and tumor type between the two groups, which were comparable.Complication group had longer hospitalization than noncomplication group (24 d vs 15 d,P<0.001), and the differences were statistically significant.In complication group, 18 patients had pancreatic fistula, 13 had peritoneal infection, 7 had gastric empty dysfunction, 8 had bleeding, 2 had bile fistula and 2 had incision infection after PD.The postoperative plasma PCT level in patients with gastric empty dysfunction, bleeding, bile fistula and incision infection was not statistically different from those in noncomplication group (all P>0.05), but the plasma PCT level in patients with pancreatic fistula and peritoneal infection on 3 d and 5 d after PD was significantly higher than those in noncomplication group, and the difference was statistically significant (all P<0.05).The combination of plasma PCT and WBC on 3 d and 5 d after PD was superior to PCT or WBC alone in predicting pancreatic fistula (sensitivity 88.9%, 72.7%;specificity 68.5%, 78.2%) and abdominal infection (sensitivity 100%, 100%;specificity 45.9%, 44.4%).Conclusions Plasma PCT could predict the occurrence of abdominal infection and pancreatic fistula after PD.The combination of PCT and WBC might be more valuable in predicting abdominal infection and pancreatic fistula.