摘要目的 研究肿瘤相关基因Gankyrin在胰腺癌组织中表达的临床意义.方法 采用免疫组织化学染色法检测Gankyrin在62例胰腺癌及对应癌旁组织中的表达情况,分析其与肿瘤病理参数的相关性及其对胰腺癌患者预后的影响.结果 胰腺癌及癌旁正常胰腺组织Gankyrin阳性表达率分别为72.5％(45/62)及19.4％(12/62),癌组织的阳性表达率显著高于癌旁组织,差异有统计学意义(P＜0.001).胰腺癌组织Gankyrn表达与TNM分期、肿瘤分化及转移相关(P＜0.05),而与患者年龄、性别及肿瘤位置无关(P＞ 0.05);Gankyrin阳性者的术后3年生存率为17.8％ (8/45),阴性者为41.2％(7/17),Gankyrin阳性表达者术后生存时间显著短于阴性表达者(P=0.034).结论 Gankyrin在胰腺癌组织中高表达,其表达与患者预后不良密切相关.

abstractsObjective To investigate the clinical significance of tumor related gene gankyrin expression in pancreatic cancer.Methods The immunohistochemical staining was performed to study the gankyrin expression in 62 pairs of pancreatic cancer and matched non-tumor tissues.The correlations ofgankyrin expression with pathological parameters and the influences on the prognosis were analyzed.Results Ggankyrin positivity in pancreatic cancer and matched non tumor tissue was 2.5％ (45/62)and 19.4％ (12/62),respectively.The positivity of gankyrin was significantly higher in pancreatic cancer compared with matched non-tumor tissues,and the differences were statistical significant (P ＜ 0.01).Gankyrin expression in pancreatic cancer tissues were significantly correlated with TNM stage,differentiation and metastasis (P ＜ 0.05),but not with age,gender or tumor location (P ＞ 0.05).The 3-year survival rates of patients with positive and negative gankyrin expression were 17.8 ％ (8/45)and 41.2％ (7/17),respectively.Patients with positive gankyrin expression had a significantly shorter survival period compared with these with negative expression in pancreatic cancer tissues (P =0.034).Conclusions Gankyrin was overexpressed in pancreatic cancer,which was correlated with poor prognosis.