摘要目的　观察慢性氟中毒大鼠血 脂及载脂蛋白变化。方法　给大鼠饮用高氟水半年致慢性氟中毒，测定血清中总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇 （LDL-c）、载脂蛋白AI（APO AI）、载脂蛋白B（APO B）及动脉硬化指数（A I）、冠心指数（R-CHD）。结果　实验组血清中TC、TG、HDL-c、LDL-c、APO A I、APO B及AI、R-CHD均高于对照组，差异有显著意义（P<0.05）。结论　慢性氟中毒大鼠血脂及载脂蛋白呈异常升高变化， 并有促进动脉粥样硬化趋势。

abstractsObjective　To observe the change of lipidemia and lipoprotein in wistar rats with fluorosis.Methods　14 wistar rats were fed normal food with hyper concentration of NaF water (100 mg/L) for six months,the TC,TG,HDL-c,LDL-c,APO AI APO B and AI,R-CHE were measured in serum.Results　The result show that there are an increace of T C,TG,HDL-c,LDL-c,APO AI，APO B and AI,R-CHD compared with normal rats (P <0.05).Conclusions　The result indicate that the fluorosis can increase the lipidemia and lipoprotein in rats with fluorosis and lead to athero selerosis.