鼠疫菌抗原CTL表位预测方法的建立
Study on prediction of CTL Epitope for Yersinia pestis antigens
目的 建市鼠疫菌抗原CTL表位的预测方法 ,为鼠疫菌表位组学研究提供行之有效的研究平台.方法 采用nHLAPred,BIMAS和SYFPEITHI网络预测法对IJcrV抗原的CTL表位进行预测.结果 预测得到了LcrV的特异性CTL优势表位:V8~16 NPQHFIEDL,V311~319 KYDSVMQRL和V258~264SYNKDNNEL.结论 结合小同预测方法 进行工细胞表位的预测,可得到鼠疫菌LcrV抗原的CTL表位,具有较高的准确率,可为表位网谱的绘制提供参考依据.
更多Objective To establish a method predicting CTL epitopes of antigens in Yersinia pestis,which provides an effective research plan for epitnmics in Yersinia pestis.Methods CTL epitopes were predicted by nHLAPred.BIMAS and SYFPEITHI.Results CTL epitopes of LcrV antigen were detected as V8-16 NPQHFIEDL,V311-319 KYDSVMQRL and V258-264 SYNKDNNEL.Conclusions Prediction of CTL epitope can be used to make epitope mapping because of its hiigh accuracy.It may provide a reference for the epitope mapping plan.
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