摘要妊娠期高血压疾病是妊娠期特有的疾病,是导致孕产妇及围生儿死亡率升高的主要原因.由于病因和发病机制尚未完全明确,普遍认为胎盘损伤是发病的中心环节.近年来,有研究表明,缺氧诱导因子-1(hypoxia inducible factor-1,HIF-1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体家族是妊娠期高血压疾病相关的重要调节因子,文中主要对这两种调节因子及二者与妊娠期高血压疾病的关系进行综述.

abstractsHypertensive disorder complicating pregnancy is a special disease during pregnancy,and it is the key reason for rising death rate of maternal and perinatal infants.Its etiology and pathogenesis are not yet fully elucidated.It is generally accepted that placenta damage plays a central role in hypertensive disorders complicating pregnancy.In recent years,studies have shown that hypoxia inducing factor-1 (HIF-1),vascular endothelial growth factor (VEGF)and its receptor family are important regulatory factors associated with hypertensive disorders complicating pregnancy.In this article,we discussed the relationship between the two factors and hypertensive disorders complicating pregnancy.