摘要神经球蛋白是一个与氧有高亲和性且多表达于脊椎动物脑组织的单体球蛋白.许多研究证实,神经球蛋白在缺血缺氧等致神经系统损伤的过程中发生表达变化,可能起到保护作用.神经球蛋白的作用机制主要包括清除自由基、对抗氧化应激、对抗细胞凋亡,还可以作为信号转导物质促进下游磷脂酰肌醇-3-激酶/丝氨酸-苏氨酸蛋白激酶(phosphatidylinositol-3-kinase/protein serine threonine kinase,PI3K/AKT)信号的激活而增加细胞活性.砷暴露导致氧化应激及凋亡的发生,因此,神经球蛋白可能在砷暴露导致的神经系统损伤中起到保护作用.文中总结了神经球蛋白在神经系统的表达变化及保护作用,展望神经球蛋白在地方性砷中毒导致的神经系统损伤中的保护作用.

abstractsNeuroglobin (Ngb) is a globin with high affinity to oxygen and is specifically expressed in the brain of vertebrates.Many studies show that Ngb's expressions change and it may have protective effects in nervous system injury,such as ischemia/hypoxia.Mechanisms of the Ngb's protective role include free radicals scavenging,anti-oxidative stress,as well as anti-apoptosis.Ngb can also play a transduction signal to increase downstream phosphatidylinositol-3-kinase/protein serine threonine kinase (PI3K/AKT) signal activities.Arsenic exposure can lead to oxidative stress and apoptosis,Ngb may play a protective role in nervous system injury.In this article,we summarized expression changes and protective role of neuroglobin in nervous system injuries,and out looked the protective role of neuroglobin in endemic arsenic poisoning induced nervous system injury.