摘要砷的致癌分子机制尚未完全阐明,表观遗传学作用参与了砷诱导肿瘤发生过程.作为一种重要的表观遗传机制,组蛋白修饰在肿瘤发生发展过程中发挥关键作用,但是目前关于组蛋白修饰在砷致癌过程中作用的研究还较少.因此,深入研究组蛋白修饰在砷致癌过程中的作用,不仅能丰富砷的表观作用靶点,而且对于推进砷致癌作用机制的阐明具有重要意义.

abstractsThe mechanisms by which arsenic induces tumorigenesis have not been fully elucidated. Genetics is involved in the carcinogenesis induced by arsenic. As an important epigenetic mechanism, histone modifications play a critical role in the carcinogenesis and development of tumor. However, there is still less research on the role of histone modifications during the carcinogenesis of arsenic. So, further studies on the possible role of histone modifications in arsenic carcinogenesis not only enrich the epigenetic targets of arsenic,but also have important implications for the elucidation of the mechanism of arsenic carcinogenesis.