摘要谷氧还蛋白系统(Grxs)是重要的抗氧化系统之一,由谷氧还蛋白、谷胱甘肽、谷胱甘肽还原酶和烟酰胺腺嘌呤二核苷酸磷酸组成.谷氧还蛋白作为有氧化还原酶作用的小蛋白质,还具有脱谷胱甘肽、还原抗氧化剂、重组含铁硫族酶的作用.在细胞、动物和植物研究中,砷及其代谢产物能诱发活性氧、产生自由基、引发氧化应激反应,而Grxs在砷中毒机制中发挥抗氧化作用,对氧化还原的平衡至关重要.因此,作者对Grxs在砷中毒机制中的抗氧化作用进行综述.

abstractsThe glutaredoxin system (Grxs) is one of the important antioxidant systems,including glutaredoxin,glutathione,glutaredoxin reductase and nicotinamide adenine dinucleotide phosphate.Glutaredoxin is a small protein as oxidoreductases with the function of deglutathionylation,reducing antioxidants and recombination of iron-sulfur enzymes.In studies of ceils,animals and plants,arsenic and its metabolites can induce reactive oxygen species,generate free radicals and trigger oxidative stress.The Grxs plays an essential role of antioxidant and maintains redox state in arsenic poisoning.Therefore,the article reviewed the anti-oxidation effect of Grxs in arsenic poisoning.