摘要目的 了解新疆牛羊源布鲁菌对药物的敏感性.方法 采用纸片扩散法,选择氨基糖苷类、大环内酯类、磺胺类、四环素类、β-内酰胺类、氟喹诺酮类、氯霉素类和利福霉素类8大类抗生素的19种药物对2010-2016年新疆地区分离的57株牛羊源布鲁菌进行药物敏感试验.结果 57株布鲁菌对多西环素、四环素、链霉素、妥布霉素、庆大霉素、阿米卡星、阿莫西林、氧氟沙星、氟罗沙星、环丙沙星、氯霉素敏感性较高,敏感率均在90％以上;而对阿奇霉素、克拉霉素、复方新诺明耐药性较高,耐药率均在80％以上.结论 新疆地区牛羊源布鲁菌对四环素类、氨基糖苷类、β-内酰胺类、氟喹诺酮类及氯霉素类药物较敏感.

abstractsObjective To explore the drug sensibility of Brucella from bovine and sheep in Xinjiang.Methods Using paper diffusion method,19 drugs of 8 kinds of antibiotics including aminoglycosides,macrolides,sulfonamides,tetracyclines,β-lactams,fluoroquinolones,chloramphenicols and rifamycins,were tested.Drug sensitivity test was conducted on 57 Brucella strains isolated from bovine and sheep in Xinjiang from 2010 to 2016.Results The 57 Brucella strains were highly sensitive to doxycycline,tetracycline,streptomycin,tobramycin,gentamicin,amikacin,amoxicillin,ofloxacin,fleroxacin,ciprofloxacin and chloramphenicol,with the sensitivity rates were all higher than 90％;and they were highly resistance to azithromycin,clarithromycin and bactrim,with the drug resistance rates were all higher than 80％.Conclusion Brucella from bovine and sheep in Xinjiang is sensitive to tetracyclines,aminoglycosides,β-1actams,fluoroquinolones and chloramphenicols.