摘要关节软骨缺损发病率较高,因自身修复能力有限,损伤后难以完成再生修复.血小板浓缩物(PCs)是全血经离心分离等步骤后获得的以浓缩血小板为主的一种血液制品,其富含高浓度血小板、白细胞、各类生长因子和纤维蛋白原,能促进组织损伤的修复与再生,已被广泛应用于骨科、运动医学领域.多项研究表明,PCs在修复关节软骨缺损、促进关节软骨再生方面具有显著作用.文中对PCs的分类、制备方法、作用机制以及在修复关节软骨缺损方面的动物和临床实验等研究进展进行综述.

abstractsThe incidence of articular cartilage defects is high.Due to limited self-repair ability,it is difficult to complete regenerative repair after injury.Platelet concentrates (PCs) is a kind of blood product obtained after centrifugation and other steps of whole blood with high concentration of platelet as the main component,which includes platelets,white blood cells,various growth factors and fibrinogen,it can promote the repair and regeneration of tissue defects and it has been widely used in orthopedics and sports medicine.PCs have been shown to play a significant role in repairing articular cartilage defects and promoting cartilage regeneration.In this paper,the PCs classification,preparation methods,mechanism of action and its animal and clinical trials in repairing articular cartilage defects are reviewed.