摘要目的:分析甘肃省庆阳市人间布鲁菌病（以下简称布病）流行特征，为进一步加强防控措施提供依据。方法:自中国疾病预防控制信息系统收集2010-2019年庆阳市人间布病病例资料；自甘肃省统计年鉴收集人口数据；自庆阳市农业农村局收集羊只检疫信息等资料。运用描述流行病学方法分析2010-2019年庆阳市人间布病发病三间分布特征。采用Spearman秩相关检验分析人间布病发病数与羊只血清阳性率之间的相关性。结果:2010-2019年庆阳市共报告人间布病2 387例，年均发病率为1.05/万，无死亡病例。2015年发病最多，发病率为2.98/万；4-7月份发病多见，占总病例数的52.49%（1 253/2 387）。发病人数最多的是镇原县（476例），其次为环县（456例）、合水县（410例）。病例男女性别比为2.89∶1.00（1 773∶614）；年龄以30~59岁为主，占总病例数的67.53%（1 612/2 387）；职业以农民为主，占总病例数的91.54%（2 185/2 387）。各年度羊只血清阳性率范围为0.33%~4.79%，经比较差异有统计学意义（χ 2 = 10 412.594， P < 0.01）。人间布病发病数与羊只血清阳性率之间呈正相关（ rs = 0.802， P < 0.05）。庆阳市人间布病卫生系统防控措施以宣传和加强医疗救治为主，而农牧部门以羊只免疫为主。 结论:庆阳市人间布病发病时间存在明显的季节性特征，呈春夏季高发；发病人群主要以男性青壮年为主；发病地点主要分布于畜牧养殖业较多的地区。防控措施主要是控制羊间布病发病，同时兼顾高危人群的行为干预。

abstractsObjective:To analyze the epidemic characteristics of human brucellosis in Qingyang City, Gansu Province from 2010 to 2019, and to provide basis for further strengthening of prevention and control measures.Methods:Data of human brucellosis cases in Qingyang City from 2010 to 2019 were collected from China Disease Prevention and Control Information System, population data were collected from Statistical Yearbook of Gansu Province, and quarantine information on sheep were collected from Agricultural and Rural Bureau of Qingyang City. Descriptive epidemiological method was applied to analyze the time, location and population distribution features of human brucellosis from 2010 to 2019. Spearman rank correlation test was used to analyze the correlation between the number of human brucellosis and the positive rate of sheep serum detection.Results:From 2010 to 2019, 2 387 cases of human brucellosis were reported in Qingyang City, the average annual incidence rate was 1.05/10 000, and no deaths were reported. In 2015, the incidence was the highest, with an incidence rate of 2.98/10 000. From April to July, 52.49% (1 253/2 387) of the overall cases were reported. The largest number of cases was in Zhenyuan County (476 cases), followed by Huan County (456 cases) and Heshui County (410 cases). The ratio of male to female was 2.89∶1.00 (1 773∶614); majority of cases were 30-59 years old, accounting for 67.53% (1 612/2 387) of the total cases; and the occupation was mainly farmers, accounting for 91.54% (2 185/2 387). The positive rate of sheep serum detection ranged from 0.33% to 4.79% in each year, and the difference was statistically significant (χ 2 = 10 412.594, P < 0.01). There was a positive correlation between the number of human brucellosis and the positive rate of sheep serum detection ( rs = 0.802, P < 0.05). The health system of prevention and control measures mainly focused on propaganda and enhancing medical treatment, while the agriculture and animal husbandry department relied mainly on sheep immunization. Conclusions:The seasonal characteristic of the onset time of human brucellosis is obvious, with a high incidence in spring and summer. The main population of the disease is young and middle-aged men; the location of the disease is mainly distributed in areas with more animal husbandry. The main prevention and control measures are to control the incidence of brucellosis among sheep, and take into account the behavioral intervention of high-risk groups.