摘要真菌毒素是一类数量众多、种类繁杂的次级代谢产物，能够在哺乳动物中诱发毒理学效应。T-2毒素和黄绿青霉素（CIT）是常见的真菌毒素，很多农产品在收获或储存过程中受到其不同程度的污染，毒素水平取决于诸如土壤的温度和湿度、储藏条件等环境因素。两种真菌毒素对人类健康构成潜在危害，其中，T-2毒素导致发育期骺板软骨变性坏死，产生与大骨节病相似的病理性改变；CIT引起心肌损伤，与地方性克山病的爆发相关联。因此，T-2毒素和CIT的致病作用受到广泛的社会关注。本文综述了T-2毒素和CIT的产生、理化性质、毒理学效应、致病机制及防治措施等方面的研究进展。

abstractsMycotoxin covers a large number and variety of secondary metabolites, which can induce toxicological effects in mammals. T-2 toxin and citreoviridin (CIT) are common mycotoxins. Many agricultural products are polluted to varying degrees during harvest or storage. Their toxin levels depend on environmental factors such as temperature and humidity of the soil, storage conditions and so on. These two mycotoxins pose potential health hazards to human beings. Among them, T-2 toxin causes degeneration and necrosis of epiphyseal plate cartilage in the development stage, which produces pathological changes similar to Kashin-Beck disease; CIT causes myocardial damage, which is associated with the outbreak of endemic Keshan disease. Therefore, the pathogenicity of T-2 toxin and CIT has been widely concerned. In this paper, the production, physicochemical properties, toxicological effects, pathogenesis and control measures of T-2 toxin and CIT are reviewed.