摘要目的:探讨锝亚甲基二膦酸盐（ 99mTc-MDP）全身骨显像对早期布鲁氏菌病（简称布病）患者骨关节损伤的诊断价值。 方法:根据《布鲁氏菌病诊断》（WS 269-2019），结合流行病学史、临床表现以及血清学检测，选取2020年11月至2021年4月由青海省地方病预防控制所布病预防控制科检查确诊的没有接受任何药物治疗的15名早期布病患者（病程在6个月之内）为研究对象，对患者行 99mTc-MDP全身骨显像，评价图像并分析病变情况。 结果:15例早期布病患者 99mTc-MDP全身骨显像均表现异常，核素异常浓聚部位主要出现在第8至12胸椎（T8-12）、第1至2腰椎（L1-2）和L4-5。其中，胸椎异常表现为T8、T9、T10、T11、T12异常各1例；腰椎异常表现为L1、L2异常各1例，L4异常4例，L5异常5例。 结论:早期布病患者 99mTc-MDP全身骨显像异常，骨显像对早期布病患者骨关节损伤的诊断具有一定价值。

abstractsObjective:To investigate the diagnostic value of 99mTc-methylenediphosphonate(MDP) whole body bone scintigraphy in early brucellosis patients with bone and joint injuries. Methods:According to the Diagnosis for Brucellosis (WS 269-2019), combined with epidemiological history, clinical manifestations and serological tests, from November 2020 to April 2021, 15 early brucellosis patients (the course of disease was within 6 months) who had not received any drug treatment diagnosed at the Department for Brucellosis Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control were selected as the research subjects, and 99mTc-MDP whole body bone scintigraphy was performed on the patients to evaluate the images and analyze the pathological changes. Results:The 99mTc-MDP whole body bone scintigraphy of 15 patients with early brucellosis showed abnormalities, and the abnormal concentration of radionuclides mainly occurred in the 8th to 12th thoracic vertebrae (T8-12), the 1st to 2nd lumbar vertebrae (L1-2) and L4-5. Among them, the thoracic vertebrae abnormalities were T8, T9, T10, T11 and T12 in 1 case each; lumbar vertebrae abnormalities were 1 case of L1, 1 case of L2, 4 cases of L4, and 5 cases of L5. Conclusions:The 99mTc-MDP whole body bone scintigraphy is abnormal in patients with early brucellosis. Bone scintigraphy has certain value in the diagnosis of bone and joint injuries in patients with early brucellosis.