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目的:探索碘过量对成人抗氧化能力及血脂水平的影响。方法:在山东省和山西省不同碘营养水平地区开展现况调查，收集成人空腹晨尿和静脉血，检测尿碘含量和血清超氧化物歧化酶（SOD）、丙二醛（MDA）、总胆固醇（TCHO）、甘油三酯（TG）、载脂蛋白A1（apoA1）、载脂蛋白B（apoB）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。根据调查村人群尿碘中位数，分为适碘组（100~299 μg/L）和碘过量组（≥300 μg/L）。应用多元线性回归分析碘营养及其他因素对氧化应激指标和血脂水平的影响。应用偏相关分析探讨碘营养与氧化应激指标以及血脂水平的关系。结果:共纳入研究对象1 049人，其中适碘组471人、碘过量组578人。适碘组和碘过量组人群尿碘分别为228.70（157.02，341.49）、558.73（298.06，985.06）μg/L；血清SOD水平分别为12.60（10.83，14.10）、11.29（9.18，13.10）U/ml，组间比较差异有统计学意义（ U = 92 697.50， P < 0.001）；血清TG、HDL-C、apoB水平比较，差异均有统计学意义（ U = 108 879.50、96 613.50、99 050.50，均 P < 0.05）。多元线性回归结果显示，在排除年龄、性别、身体质量指数（BMI）因素后，碘营养与血清SOD、HDL-C水平均呈负相关[标准回归系数（ β）= - 0.196、- 0.294，均 P < 0.001]。偏相关分析结果显示，碘营养与血清SOD、HDL-C水平均呈负相关[相关系数（ r）= - 0.16、- 0.09，均 P < 0.05]。 结论:碘过量摄入可对人体氧化应激及脂代谢产生影响。

Objective:To study the effect of iodine excess on antioxidant capacity and blood lipid in adult.Methods:A survey was conducted in areas with different iodine nutrition levels in Shandong and Shanxi provinces to collect fasting morning urine and venous blood samples of adults. Urinary iodine, serum levels of superoxide dismutase(SOD), malondialdehyde (MDA), total cholesterol (TCHO), triglyceride (TG), apolipoprotein A1 (apoA1) and apolipoprotein B (apoB), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were determined. According to the median urinary iodine of the population in the investigated village, they were divided into appropriate iodine group (100-299 μg/L) and iodine excess group (≥300 μg/L) . Multiple linear regression was used to analyze the effects of iodine nutrition and other factors on oxidative stress indexes and blood lipids. Partial correlation analysis was used to analyze the relationship between iodine nutrition and oxidative stress indexes and blood lipids.Results:A total of 1 049 subjects were included, including 471 in the appropriate iodine group and 578 in the iodine excess group. The median (quartile) urinary iodine of the appropriate iodine group and the iodine excess group was 228.70 (157.02, 341.49) and 558.73 (298.06, 985.06) μg/L, respectively. The serum SOD level of the appropriate iodine group and the iodine excess group was 12.60 (10.83, 14.10) and 11.29 (9.18, 13.10) U/ml, respectively, and the difference between the groups was statistically significant ( U = 92 697.50, P < 0.001). There were statistically significant differences in serum TG, HDL-C and apoB levels between the appropriate iodine group and the iodine excess group ( U = 108 879.50, 96 613.50, 99 050.50, P < 0.05). The results of multiple linear regression showed that after excluding age, gender and body mass index (BMI), there was a negative correlation between iodine nutrition and serum SOD and HDL-C levels [standard regression coefficient ( β) = - 0.196, - 0.294, P < 0.001]. Partial correlation analysis showed that there was a negative correlation between iodine nutrition and serum SOD and HDL-C levels [correlation coefficient ( r) = - 0.16, - 0.09, P < 0.05]. Conclusion:Excessive iodine intake affects oxidative stress and lipid metabolism in human body.