摘要目的 研究参附注射液对兔肺挫伤的治疗效果及可能机制.方法 新西兰白兔16只随机分为两组:参附(应用参附注射液)组和对照组各8只.制作肺挫伤模型,60 min后分别应用参附注射液和林格液治疗.在6 h后将动物处死,取右肺检测其干湿比(W/D),测定肺组织中髓过氧化物酶(MPO)活性、核转录因子(NF-κB)的表达以及细胞间黏附分子-1(ICAM-1)的表达,并观察肺组织病理结构的变化.结果 参附组W/D和MPO明显低于对照组(P<0.01),肺组织中NF-κB和ICAM-1的表达也明显低于对照组(P<0.01),肺组织病理变化较对照组轻.结论 参附注射液对肺损伤有较好的治疗作用.

abstractsObjective To investigate the effects of Shen-fu injection on pulmonary contusion rabbits. Meth-ods Sixteen rabbits were randomly divided into 2 groups: the treatment group (Shen-fu group) and the control group. The animals were induced the pulmonary contusion models. After 60min, the animals in Shen-fu group re-ceived Shen-fu injection received 5 ml/kg, and those in control group 5 ml/kg LRS. The animals were killed six hours later, the right lung tissue wet-to-dry (W/D) ratio and myeloperoxidase (MPO) activity were obtained,the pro-tein expression of nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) were also detec-ted. Results The lung tissue W/D, MPO, and the protein expression of NF-κB and ICAM-1 were decreased evi-dently in Shen-fu group (P<0. 01). The morphologic and ultrastructural damages in Shen-fu group were milder than in control group. Conclusion Shen-fu injection is effective on pulmonary contusion rabbits.