摘要目的 探讨如何调整用药剂量,克服过大偏差.方法 以概率论和数理统计为依据,运用黄金区域法对注射用头孢孟多酯钠不良反应进行大样本调查和研究.结果 给药剂量在黄金区域之内取值和之外取值的不良反应总体率分别为0.014%和0.037%,在黄金区域内取值显著低于黄金区域外取值的不良反应率.特别需要注意的是:用药剂量低于黄金区域不良反应率显著增加,是黄金区域内不良反应率的4倍多.结论 在黄金区域内给药对降低药物不良反应行之有效,且简便易行;在不到经验范围1/4黄金区域内包含药物治疗的合适剂量的概率接近70%.

abstractsObjective Inaccurate dosing is an important cause of medical malpractice, how to adjust the medication dose to overcome the excessive deviation will be discussed in this paper. Methods Gold zone method was proposed on the basis of the probability theory and mathematical statistics for handling inaccurate dosing problems. Investigation and study in large sample size was carried out on adverse reactions of Cefamandole Nafate for Injection by adopting the method. Results The conclusions from the super large sample size test indicate that there is highly significant difference of total adverse reaction rates between taking values within and outside golden zone of dosage, and the adverse reaction rate of taking values within golden zone is significantly lower than that of outside golden zone. It is noteworthy that when dosage was lower than golden zone,the adverse reaction rate was significantly increased,which is more than 4 times of that within golden zone. Conclusion It is effective measures and simply and easy to apply that taking values within golden zone of dosage reduce adverse drug reactions,probability within golden zone less than 1/4 range of experience that contains the actual demand of the body up to 70%.