摘要目的：探讨无创呼吸机用于COPD合并慢性Ⅱ型呼吸衰竭的临床疗效及安全性。方法根据数字表法随机将115例 COPD 合并慢性Ⅱ型呼吸衰竭患者分为观察组（n ＝59）和对照组（n ＝56）。对照组采取常规对症治疗，观察组在对照组治疗基础上结合无创呼吸机治疗。比较两组治疗前和治疗48 h 后 HR、RR、PaCO2、PaO2、一秒用力呼气容积（FEV1）、FEV1／用力肺活量（FEV1／FVC）变化。结果治疗前，两组 HR、RR、PaCO2、PaO2、FEV1、FEV1／FVC 差异均无统计学意义（均 P ＞0．05）。治疗后，对照组 HR、RR、PaCO2、PaO2、FEV1、FEV1／FVC 分别为（90．16±4．15）次／min、（23．17±1．63）次／min、（59．68±5．85）mmHg、（69．16±5．26）mmHg、（2．65±0．25）L、（65．47±1．97）％，观察组 HR、RR、PaCO2、PaO2、FEV1、FEV1／FVC 分别为（82．93±3．76）次／min、（19．02±1．57）次／min、（50．82±6．53）mmHg、（78．06±5．48）mmHg、（2．96±0．31）L、（72．38±2．15）％，两组差异均有统计学意义（t ＝9．800、13．907、7．649、8．877、5．917、17．942，均 P ＜0．05）；两组治疗期间未见不良反应发生。结论无创呼吸机治疗 COPD 合并慢性Ⅱ型呼吸衰竭的临床疗效显著，安全可靠，值得进一步推广应用。

abstractsObjective To investigate the treatment of noninvasive ventilator in chronic obstructive pulmonary disease merge chronic type Ⅱ respiratory failure and to analysis its clinical efficacy and safety.Methods According to the random number table,115 cases were randomly divided into two groups,the observation group (n =59)and the control group(n =56).The control group received conventional symptomatic treatment,while the observation group therapy was combined with non -invasive ventilation in the basis of the control group.The changes of HR,RR, PaCO2 ,PaO2 ,Forced expiratory volume in one second 1 (FEV1 ),Forced expiratory volume in one second 1 (Forced expiratory volume in one second 1,FEV1 /FVC)were compared between the two groups before and after treatment 48h.Results Before treatment,there were no significant differences in HR,PaCO2 ,RR,FEV1 ,PaO2 ,FEV1 /FVC (P >0.05).After the treatment,in the control group,HR,RR,PaCO2 ,PaO2 ,FEV1 and FEV1 /FVC were respectively (90.16 ±4.15)beats/min,(23.17 ±1.63)beats/min,(59.68 ±5.85)mmHg,(69.16 ±5.26)mmHg,(2.65 ± 0.25)L and(65.47 ±1.97)%.In the observation group,HR,RR,PaCO2 ,PaO2 ,FEV1 and FEV1 /FVC were respectively (82.93 ±3.76)beats/min,(19.02 ±1.57)beats/min,(50.82 ±6.53)mmHg,(78.06 ±5.48)mmHg,(2.96 ± 0.31)L and (72.38 ±2.15)%.The difference was statistically significant(t =9.800,13.907,7.649,8.877,5.917, 17.942,all P <0.05).No adverse reactions occurred during the treatment.Conclusion The clinical efficacy of non-invasive ventilator in the treatment of COPD associated with chronic type Ⅱ respiratory failure is significant,safe and reliable,which has important research value,and is worthy of further application.