摘要目的 探讨卡马西平联合恩必普治疗癫痫的疗效及对智力与脑电图的影响.方法 选取86例癫痫患者,采用随机数字表法分为观察组和对照组,每组43例.观察组使用卡马西平联合恩必普治疗,对照组使用卡马西平治疗.比较两组患者临床疗效,癫痫发作持续时间和发作次数,智力情况,P300波幅值和波潜伏期,不良反应.结果 观察组临床总有效率显著高于对照组[93.02%(40/43)比74.42%(32/43),χ2=5.460,P<0.05].观察组的癫痫发作持续时间短于对照组[(2.31±0.26)次/min比(3.16±0.38)次/min,t=12.106,P<0.05]、发作次数少于对照组[(0.82±0.11)次/年比(1.34±0.15)次/年,t=18.332,P<0.05].观察组的自觉辨别能力、类同比较能力、比较推理能力、系列关系能力、抽象推理能力评分均显著高于对照组(t=7.557、13.075、2.082、7.615、9.903,均P<0.05).观察组的SPM分级水平改善效果优于对照组(t=4.705,P<0.05).观察组的P300波幅值显著高于对照组[(6.87±0.68)μV比(5.24±0.51)μV,t=12.575,P<0.05]、P300波潜伏期显著低于对照组[(305.32±17.34)ms比(326.45±19.15)ms,t=5.363,P<0.05].观察组和对照组的不良反应率比较差异无统计学意义(P>0.05).结论 卡马西平联合恩必普治疗癫痫,能减少患者的发作持续时间和发作次数,可有效改善患者智力水平和脑电图情况,临床疗效良好,安全性高.

abstractsObjective To study the effect of carbamazepine and ENP in the treatment of epilepsy and its influence on intelligence and electroencephalogram .Methods Eighty-six patients with epilepsy were enrolled . According to the random number method,they were divided into observation group and the control group ,43 cases in each groups.The observation group was given carbamazepine combination with ENP ,while the control group was given carbamazepine.The duration of epileptic seizure and the number of seizures ,intelligence,P300 wave amplitude and wave latency,and adverse effects were compared between the two groups .Results The total effective rate in the observation group was significantly higher than that in the control group [93.02%(40/43) vs.74.42%(32 /43)] (χ2 =5.460,P <0.05).The duration of seizure of the observation group was shorter than that of the control group [(2.31 ±0.26)times /min vs.(3.16 ±0.38)times /min](t =12.106,P <0.05),and the frequency of seizures of the observation group was shorter than that of the control group [(0.82 ±0.11)time/year vs.(1.34 ±0.15)time/year](t =18.332,P <0.05).The ability of self-discernment,analogical comparison,comparative reasoning,series relation and abstract reasoning ability of the observation group were significantly higher than those of the control group (t =7.557,13.075,2.082,7.615,9.903,all P <0.05).The improvement of SPM level in the observation group was better than that in the control group (t =4.705,P <0.05).The amplitude of P300 wave of the observation group was significantly higher than that of the control group [(6.87 ±0.68)μV vs.(5.24 ±0.51)μV](t =12.575,P <0.05). The latency of P300 wave of the observation group was significantly lower than that of the control group [(305.32 ± 17.34)ms vs.(326.45 ±19.15)ms](t =5.363,P <0.05).There was no statistically significant difference in the incidence rate of adverse reaction between the observation group and the control group (P >0.05).Conclusion The combination of carbamazepine and ENP in the treatment of epilepsy can reduce the duration and frequency of seizures,and improve the intelligence level and electroencephalogram .The clinical efficacy is good and the safety is high .