摘要目的:探讨电动微针联合重组胶原蛋白液体敷料、复方甘草酸苷片及丁酸氢化可的松软膏治疗轻中度儿童斑秃的效果及安全性。方法:本研究为前瞻性研究。选取2023年11月至2024年6月遵义市妇幼保健院皮肤科收治的轻中度儿童斑秃72例为研究对象，按照就诊顺序随机分为电动微针联合治疗组（试验组）和无电动微针联合治疗组（对照组）。所有患者口服复方甘草酸苷片及丁酸氢化可的松软膏外用治疗；试验组采用电动微针针刺斑秃皮损并同时涂抹重组胶原蛋白液体敷料；对照组不加用电动微针治疗，仅涂抹重组胶原蛋白液体敷料于皮损处。连续治疗12周，比较两组治疗效果、不良反应发生情况。治疗结束后随访3个月，观察复发情况。结果:试验组有效率为81.58%（31/38），对照组有效率为73.53%（25/34），两组差异无统计学意义（ χ2=0.67， P=0.412）；试验组治愈率为57.89%（22/38），对照组治愈率为47.06%（16/34），差异无统计学意义（ χ2=0.85， P=0.358）；试验组起效时间为（3.16±0.73）周，短于对照组的（4.60±1.08）周（ t=5.15， P < 0.001）；试验组不良反应发生率为7.89%（3/38），对照组不良反应发生率为0，两组差异无统计学意义（ Fisher值=0.24， P=0.242）；试验组复发率为6.45%（2/31），对照组复发率为12.00%（3/25），两组差异无统计学意义（ χ2=0.06， P=0.801）。 结论:电动微针联合重组胶原蛋白液体敷料、复方甘草酸苷片和丁酸氢化可的松软膏治疗轻中度儿童斑秃起效快，且安全、有效。

abstractsObjective:To investigate the efficacy and safety of electric microneedling combined with recombinant collagen liquid dressing, compound glycyrrhizin tablets, and hydrocortisone butyrate ointment for the treatment of mild to moderate alopecia areata in children.Methods:This is a prospective study. A total of 72 children with mild to moderate alopecia areata, admitted to the Department of Dermatology, Zunyi Maternal and Child Health Hospital from November 2023 to June 2024, were included in this study. The children were randomly assigned to either the experimental group, which received electric microneedling combined with treatment, or the control group, which received treatment without microneedling, based on the order of their visits. All patients received oral compound glycyrrhizin tablets and topical hydrocortisone butyrate ointment for treatment. In the experimental group, electric microneedling was used to puncture the alopecia lesions while simultaneously applying recombinant collagen liquid dressing. The control group did not receive electric microneedling treatment and only had the recombinant collagen liquid dressing applied to the lesions. The treatment lasted for 12 weeks. The efficacy and incidence of adverse reactions were compared between the two groups. After treatment, all patients were followed up for 3 months to check for any recurrence of this condition.Results:There was no significant difference in response rate between the experimental and control groups [81.58% (31/38) vs. 73.53% (25/34), χ2 = 0.67, P = 0.412). No significant difference in cure rate was observed between the experimental and control groups [57.89% (22/38) vs. 47.06% (16/34), χ2= 0.85, P = 0.358]. The time to effect in the experimental group was shorter than that in the control group [(3.16 ± 0.73) weeks vs. (4.60 ± 1.08) weeks, t = 5.15, P < 0.001]. The incidence of adverse reactions did not differ significantly between the experimental and control groups [7.89% (3/38) vs. 0, Fisher value = 0.24, P = 0.242]. There was no significant difference in recurrence rate between experimental and control groups [6.45% (2/31) vs. 12.00% (3/25), χ2 = 0.06, P = 0.801). Conclusions:The combination of electric microneedling, recombinant collagen liquid dressing, compound glycyrrhizin tablets, and hydrocortisone butyrate ointment provides a rapid onset of effect and is safe and effective for the treatment of mild to moderate alopecia areata in children.