摘要目的 探讨苦参碱联合甘草酸二铵治疗慢性乙型肝炎的临床效果.方法 120例患者随机分为三组,Ⅰ组给予苦参碱+甘草酸二铵治疗,Ⅱ组给予苦参碱+茵栀黄治疗,Ⅲ组给予苦参碱+复方丹参治疗,对比三组治疗前后的临床症状以及肝功能、乙型肝炎病毒标志物变化.结果 在临床症状、肝功能的改善程度以及HBeAg和HBV-DNA阴转率方面,苦参碱联合甘草酸二铵组优于其他两组,其结果具有显著性差异;后两组治疗效果无显著性差异.结论 苦参碱与甘草酸二铵联合应用治疗慢性乙型肝炎具有较好的疗效.

abstractsObjective To evaluate therapeutic efficacy of matrine and diammonium glyeymhizinate on chronic hepatitis B.Methods 120 pafients with chronic hepatitis B were divited into three groups at random,then Ⅰ group WaS given matrine and diammonium glyeyrrihizinate,Ⅱ group was treated with matrine and skimmia japoniea,Ⅲgroup Wan given matrine and salvia miltiorrhiza.The observation of clinical manffesmfions and laboratory parameters and hepatitis B viral markers were conducted before and after the management.Results In the Ⅰ group,chnical symptoms improvement and TBIL and ALT normalization were superior to the other groups,and there were significant differences between them;Otherwise,there was no significant difference between the Ⅱ group and the Ⅲ group.Conclusion These results show that the Ⅰ group with matrine and diammonium glyeyrrihizinate may be an effective,economical and sefe method for chronic hepatitis B.