摘要目的 探讨COX-2、VEGF在胃癌中的表达及与血管发生的关系.方法 采用免疫组织化学S-P法检测56例胃癌和28例正常胃黏膜组织中COX-2、VEGF的表达,计算MVD值,并进行统计学分析.结果 56例胃癌中COX-2、VEGF的阳件率分别为67.86%(38/56)和69.64%(39/56),与正常胃黏膜表达相比有统计学差异(P＜0.05).胃癌中MVD的表达量(51.04±13.26)高于正常胃黏膜表达量(18.34±8.26),有统计学差异(P＜0.05).胃癌中COX-2、VEGF的表达在不同临床分期、淋巴结转移状态有统计学差异(P＜0.05).COX-2、VEGF与MVD表达呈正相关(r=0.763,P＜0.01;r=0.825,P＜0.01),COX-2与VEGF的表达也呈正相关(r=0.621,P＜0.01).结论 COX-2、VEGF在胃癌的发生、发展中起着苇要作用,对胃癌的血管新生和发生发展有促进作用

abstractsObjective To investigate the expression of COX-2VEGF in gastric carcinoma and its relafionship with angiogenesis.Methods The expression of COX-2 and VEGF were studied by immunohistochemistry S-P method in 56 specimens of gastric carcinoma and 28 normal gastric tissues as control.The value of MVD expression Was measured.Results The positive rate of COX-2VEGF expression in gastric carcinoma were 67.86%(38/56)and 69.64%(39/56),respectively,and were statistically higher than that in normal gastric tissues(P＜0.05).The value of MVD expression was 51.04±13.26 and higher than 18.34±8.26 in normal gastric tissues(P＜0.05).The expression of COX-2VEGF were positively related with tumor differentiation degree and lymph node metastasis(P＜0.05).Statistical significant correlation were found between the expression of COX-2、VEGF and MVD(r=0.763,P＜0.01;r=0.825,P＜0.01;r=0.621,P＜0.01).Conclusion The high expression of COX-2 and VEGF are involved in gastric carcinoma development,and promote the formation of angiogenesis and the invasion and metastasis of gastric carcinoma