摘要目的 探讨血液灌流治疗尿毒症患者的疗效与安全性.方法 维持性血液透析患者31例,采用血液灌流/血液透析(HP/HD)联合治疗方法与常规血液透析(HD)方法对比(自身对比).治疗前后检测中分子物质(MMS)、血尿素、肌酐、白蛋白、血细胞及临床症状.结果 血液灌流能显著清除尿毒症患者体内的中分子物质,单次使用治疗2 h MMS平均下降25.0%,最高达44.4%.而普通透析对MMS无多大影响,两者具有显著性差异(P＜0.001).同时患者的睡眠、食欲、皮肤瘙痒有不同程度的改善,未发生其他任何不良事件和不良反应.结论 作为中分子物质的清除治疗措施,血液灌流临床使用安全、疗效可靠,无毒副反用.

abstractsObjective To investigate the effect and safety of hemoperfusion in uremia.Methods Thirty-one uremia patients were treated with combined hemodialysis resin hemoperfusion.Middle molecular substances(MMS),urea,creatinine,albumin,blood cells were detected before and after the treatment.Results MMS was reduced significantly in combined hemodialysis hemoperfusion procedure(P＜0.001).With conventional hemodialysis,a combination of hemoperfusion and bemodialysis had a better effect in MMS clearance(P＜0.001).Meanwhile,some clinical conditions(appetite,pruritus,insomnia)improved.We did not find any adverse effect.Conclusion Resin hemoperfusion can effectively clean MMS and was confumed to be a safe and risk free procedure.