摘要目的 观察参芎注射液对脑梗死患者血液流变学和纤维蛋白原含量的影响.方法 将72例急性腩梗死患者随机分为两组,参芎组(n=34)给千参芎注射液100 ml,静脉滴注,2次/d;丹参组(n=38)给予丹参注射液20 ml加入5%葡萄糖注射液100 ml中,静脉滴注,2次/d.疗程14 d.于治疗前后根据神经功能缺损程度(NDS)评分标准进行评分,并检测血液流变学及纤维蛋门原含量.结果 参芎组的总有效率(88.2%)显著高于丹参组(73.7%)(P<0.05);参芎组治疗后全血粘度、血浆粘度、红细胞聚集指数、纤维蛋白原较治疗前显著改善(P<0.05或P<0.01);丹参组治疗后仅全血粘度显著改善(P<0.05);两组治疗后比较,参芎组全血粘度(中切)、血浆粘度、纤维蛋白原显著低于丹参组(均P<0.05).结论 参芎注射液治疗急性脑梗死效果明显,可能通过改善血液流变学、降低纤维蛋白原含量起到神经保护作用.

abstractsObjective To observe the therapeutic effect of Shenxiong injection in the treatment of acute cerebral infarction and its influence on hemorheology and fibrinogen level. Methods 72 patients with acute cer-ebral infarction were randomly divided into two groups. 34 patients in Shenxiong injection group were treated with Shenxiong injection(100 ml, intravenously guttae, bid);38 patients in salvia mihiorrhiza injection group were treated with salvia mihiorrhiza(20 ml plus 100 ml parenteral solution, intravenously guttae, bid). All treat-ment lasted 14 days. NDS was introduced to evaluate the clinical efficiency. The indexes of hemorheology and fi-brinogen level in two groups was sampled before and after treatment. Results Total effctive rate in Shenxiong group(88.2%) was significantly higher than that in salvia mihiorrhiza group (73.7%) (P < 0.05) ; Compared with those before treatment, the indexes of hemorheology and fibrinogen content in Shenxiong group decreased significantly (P < 0.05, or P < 0.01) ; however, only indexes of whole blood viscosity (low and high shear rate) in salvia mihiorrhiza group decreased significantly after treatment (P < 0.05). After treatment, indexes of whole blood viscosity(moderate shear rate), plasma viscosity and fibrinogen content in Shenxiong group was signifi-cantly lower than that in salvia mihiorrhiza group (all P < 0.05). Conclusion Shenxiong injection may have neuroprotective effcts on acute cerebral infarction by improving the indexes of hemorheology and decreasing fi-brinogen content,which was better than the effect of salvia mihiorrhiza injection.