摘要目的 观察ADAM8在非小细胞肺癌中的表达及其临床病理学意义.方法 应用组织芯片和免疫组织化学技术,检测96例NSCLC组织、36例癌旁组织及12例肺良性病变组织中ADAM8蛋白的表达.结果 ADAM8在NSCLC组织、癌旁组织及良性病变组织的阳性表达率分别为82.29%(79/96)、11.11%(4/36)、16.67%(2/12),NSCLC组织与癌旁组织和良性病变组织相比较,差异有统计学意义(P<0.05),而癌旁组织与良性病变组织比较,差异无统计学意义(P>0.05);ADAM8在NSCLC患者的表达与TNM分期、淋巴结转移及远处转移密切相关(P<0.05),而与性别、年龄、肿瘤大小、肿瘤的组织学类型及分化程度无明显关系(P>0.05).结论 ADAM8的过度表达与NSCLC的TNM分期及侵袭转移存在明显的相关性,检测肺癌组织中ADAM8的表达对判断NSCLC的生物学特性有一定的参考价值.

abstractsObjective To study the expression of ADAM8 in non-small cell lung cancer and the rela-tionship with their clinical pathology. Methods The expression of ADAMS was detected by tissue microarray and immunohistechemmistry technology in 96 specimens of NSCLC tissues ,36 specimens of adjacent lung tissues and 12 specimens of benign lung tissues. Results The positive rate of ADAMS expression in NSCLC tissues, adjacent lung tissues and benign lung tissues were 82. 29% (79/96), 11.11% (4/36). 16. 67% (2/12), re-spectively ;There was a significant difference among NSCLC tissues,adjacent lung tissues and benign lung tissues (P < 0. 05),but no significant difference between adjacent lung tissues and benign lung tissues (P > 0. 05) ; ADAM8 protein expression in NSCLC tissues was closely related to TNM stages,lymph node metastasis and dis-tant metastasis (P < 0.05), but not to sex,age, tumor size, histological type and differentiation of patients (P > 0. 05). Conclusion The overexpression of ADAMS in NSCLC patients indicates that ADAMS is closely related to TNM stages, invasion and metastasis of NSCLC. Detection of ADAM8 protein may be helpful to evaluate bio-logical characteristics for NSCLC.