摘要目的探讨同型半胱氨酸与糖尿病肾病的关系以及甲钴胺对其治疗的作用效果.方法2 型糖尿病住院患者113例,均行尿微量白蛋白、血浆同型半胱氨酸检测,分析高同型半胱氨酸血症与糖尿病肾病的关系,并对糖尿病肾病伴高同型半胱氨酸血症者进行分组以研究甲钴胺对其治疗的作用效果.结果糖尿病伴糖尿病肾病组(DN+组)同型半胱氨酸明显高于正常对照组和糖尿病不伴糖尿病肾病组(DN-组),甲钴胺治疗组与对照组相比可明显降低血浆同型半胱氨酸水平.结论高同型半胱氨酸血症与糖尿病肾病关系密切,甲钴胺治疗可降低糖尿病肾病者的血浆同型半胱氨酸水平.

abstractsObjective To investigate the relationship between homoeysteine and diabetic nephropathy and the therapeutical effect of meeobalamine. Methods To collect 113 patients with type 2 diabetes who had received microalbuminuria and homocysteine, and analyzed the relationship beween homocystinemia and diabetic nephropathy, then contrasted in parallel to investigate the therapautieal effect of mecabalamine on diabetic ne-phropathy with homocystinemia. Results The homocysteine in group of diabetic nephropathy was much higher than control group and diabetic without nephropathy group. Compared to control group, mecabalamine treated group could decrease the level of homocysteine obviously. Conclusion There has close relationship between ho-moeystinemia and diabetic nephropathy, treated with meeobalamine can decrease the level of homoeysteine of di-abatie nephropathy.