摘要目的 探讨HBV血清标志物与乙肝病毒前S1抗原(Pre-S1Ag)检测结果的关系.方法 应用酶联免疫吸附试验法(ELISA)检测610患者的常规乙肝病毒血清标志物和乙肝病毒前S1抗原.结果 本组HBsAg(+)、HBeAg(+)、抗-HBcAg(+)血清样本226份,Pre-S1Ag阳性检出率为85.84%;HBsAg(+)、HBeAg(+)血清样本45份,Pre-S1Ag阳性检出率为93.33%;HBsAg(+)、抗-HBeAg(+)、抗-HBcAg(+)血清样本298份,Pre-S1Ag阳性检出率为44.97%;HBsAg(+)、抗-HBcAg(+)血清样本41份,Pre-S1Ag阳性检出率为70.73%.HBeAg(+)组Pre-S1Ag检出率为87.08%,HBeAg(-)组PreS1 Ag检出率为35.80%,两者比较差异均具有统计学意义(P＜0.05).抗-HBeAg(+)组Pre-S1Ag检出率为64.50%,抗-HBcAg(-)组Pre-S1Ag检出率为82.55%,两者比较差异均具有统计学意义(P＜0.05).结论 Pre-S1Ag是HBV复制的可靠指标,与乙肝标志物联合检测可相互补充.

abstractsObjective To discuss relationship of hepatitis B virus gerum markers and Pre-S1 antigen.Methods Analyze the markers of HBV in blood serum and pre-S1 of HBV in 610 patients with ELISA.Results Pre-S1 antigen positive detection rate was 85.84% in 226 blood serum samples of HBsAg(+),HBeAg(+) and anti-HBcAg(+),Pre-S1 antigen positive detection rate was 93.33% in 45 blood serum samples of HBsAg(+) and anti-HBeAg(+).Pre-S1 antigen positive detection rate was 44.97% in 298 blood serum samples of HBsAg (+),anti-HBeAg(+) and anti-HBcAg(+).Pre-S1 antigen positive detection rate was 70.73% in 41 blood serum samples of HBsAg(+) and anti-HBcAg(+).The detection rate of Pre-S1 Ag was 87.08% in HBeAg(+) group and 35.80% in HBeAg(-) group,and there was significant difference between two groups(P＜0.05).The detection rate of Pre-S1Ag was 64.50% in anti-HBcAg(+) group and 82.55% in anti-HBcAg(-) group,and there was significant difference between two groups(P＜0.05).Conclusion Pre-S1Ag is a credible index of HBV replication,and may be helpful for HBV markers in detecting.