摘要目的 评价血清前降钙素(PCT)检测在新生儿重症感染中早期诊断的临床意义.方法 对60例重症细菌感染新生儿和35例正常新生儿在入院时进行血清前降钙素的定量检测,同时测定C反应蛋白(CRP)和白细胞计数(WBC).观察组治疗72 h后复查PCT、CRP.结果 60例患儿入院PCT>0.5 μg/L,阳性率100%,PCT>10 μg/L以上8例,血常规血白细胞计数升高不明显,而CRP在入院时20例(48.0%)异常.治疗后痊愈58例,PCT均降至正常.结论 PCT在重症细菌感染新生儿早期是优于C反应蛋白和白细胞计数的细菌感染诊断指标.

abstractsObjective To evaluate the clinical significance of early diagnosis in procalcitionin (PCT) for neonatal severe bacterial infection. Methods The PCT were quantitative detected in 60 cases neonatal se-vere bacterial infection and 35 cases normal neonate, and the CRP and WBC were detected also. The PCT and CRP of observe group were rechecked after been treated for 72 hours. Results On admission 60 cases PCT >0.5 μg/L,the positive rate was 100%. 8 cases PCT > 10 μg/L,the WBC didn't heighten obviously. On admis-sion the CRP of 20 cases (48.0%) was abnormal. 58 cases were healing well and the PCT all decreased to nor-mal level. Conclusion In earlier period of neonatal severe bacterial infection PCT is better than CRP and WBC among the diadynamic criteria of bacterial infection.