摘要目的 探讨替米沙坦联合银杏注射液治疗早期糖尿病肾病的疗效.方法 48例糖尿病肾病早期患者,随机分为治疗组和对照组,每组24例,治疗组给予替米沙坦及银杏叶注射液,对照组给予替米沙坦,共治疗4周,观察治疗前后血压、24 h尿微量蛋白(U-Alb)、肌酐(Scr)、空腹血糖(FBS)、胆固醇(TC)、甘油三酯(TG)、血液流变学变化,评价疗效.结果 两组治疗后U-Alb、血压、SCr均有明显下降(P<0.05,P<0.01),治疗后U-Alb、TC、TG、全血粘度、纤维蛋白原、红细胞压积的下降治疗组较对照组明显,且差异有显著性(P<0.05,P<0.01).结论 替米沙坦联合银杏叶注射液治疗早期糖尿病肾病可以降低尿蛋白、降血脂,降低血粘度,纠正血液高凝状态,疗效优于单用替米沙坦,能更有效延缓肾功能恶化.

abstractsObjective To explore the effects of temisartan combined with ginkgo biloba extract injec-tion on early diabetic nephropathy(DN). Methods 48 cases with early DN were randomly assigned into treated groups, treated with ginkgo biloba extract injection and temisartan, and control group, treated with temisartan. The course lasted for 4 weeks. The changes of blood pressure, urine albumin excretion of 24 hours (U-Alb), Ser-um creatinine(Set),fasting plasma glucose(FBS),blood lipids and hemorrheology indices were examined before and after treatment. Results The lever of urine albumin excretion of 24 hours (U-Alb) was significantly de-creased. Serum croatinine(Scr), blood lipids and hemorrheology indices were all significantly improved after treatment(P<0.05, P<0.01). While they were improved significantly in treated group than that in control group(P<0.05,P<0.01). Conclusion Temisartan combined with ginkgo biloba extract injection could re-duce urine protein excretion and blood lipids,improve hemorrheology indices. Combination of temisartan ginkgo biloba extract injection had a better effect than temisartan on early DN.