摘要目的 动态观察急性心肌梗死(AMI)患者血液中自介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的动态变化,并与同期正常人群血液中细胞因子比较,探讨其在AMI患者发生发展中的作用.方法 选择AMI患者40例,与健康对照组45名作对比研究.应用放射免疫分析法测定血浆中3种细胞因子(TNF-α、IL-1β、IL-6)的含量.结果 两组比较,AMI组血液中IL-1β、TNF-α、IL-1总体水平明显高于健康埘照组.3者均在第7天达到高峰期,明显高于入院当时及随后的第1、3、5天的水平.但IL-6水平在入院当时及随后的第1、3、5天无明显升高.结论 炎性细胞因子在AMI心肌损伤过程当中起一定的作用,部分炎症因子随心肌梗死病程动态变化.

abstractsObjective To compare the inflammatory cytokines (TNF-α、IL-1β、IL-6) in the blood between AMI patients and health adult;and investigate its effect in the AMI developing.Methods We choice 40 AMI patients as the AMI group,55 health adult as the normal control.To measure the inflammatory cytokines (TNF-α,IL-1β,IL-6) in the blood of these two groups by radio immunoassay.Results The level of TNF-α and IL-1β in the AMI group is obviously higher than that of normal control (P＜0.01).There were no significant difference of IL-6 between these two groups at the days 1、3、5.The level of IL-6 in the AMI group is obviously higher at the days 7.Conclusion Inflammatory cytokines place some degree roles in the AMI progress,inflammatory cytokines changed with the course of acute myocardial infarction.