摘要目的 探讨对氯氮平治疗无效的难治性精神分裂症,合用心境稳定剂后是否有效.方法 33例氯氮平组年龄、性别,均无统计学差异,各组在把氯氮平减量的情况下,分别合用丙戊酸钠、卡马西平、碳酸锂治疗.结果 第8周末,阳性和阴性症状量表(PANSS)总分治疗下降≥20%15例(4S.4%),≥50%9例(27.2%).TESS总分比较,治疗前后无差异.结论 对氯氮平治疗无效的难治性精神分裂症患者,合用心境稳定剂后仍有一定疗效.

abstractsObjective To explore the validity of mood stabilizers to refractory schizophrenia patients who had accepted Clozapine therapy but without any efficacy.Methods 33 cases of Clozapine with no significant difference in age and gender were divided into three groups.On the basis of the reduction of Clozapine in each group,they were given Sodium valpreato,Carbamazepine and Lithium carbonate treatment respectively.Results In the end of the 8th weekend,15 cases' (45.4%) Positive and Negative Syndrome Scale (PASS) decreased≥20% and 9 cases (27.2%) decreased≥50%.TESS scores had no significant difference before and after treatment.Conclusion The combination of mood stabilizers has a certain effect to patients who had