摘要目的 探讨分化型甲状腺癌(DTC)患者治疗不同阶段血清骨钙蛋白水平及其相关影响因素.方法 97例确诊分化型甲状腺癌患者分别于手术前、手术后1个月即131-碘治疗前、131-碘治疗后1个月、131-碘治疗后半年采肘静脉血,采用放射免疫分析法测定血清T1、T4、TSH、血清骨钙蛋白(BGP)水平.结果 不同时间BGP水平差异有统计学意义(F=4497.58,P=0.000),131-碘治疗后半年血清骨钙蛋白水平均高于其他时间,131-碘治疗后1个月高于手术治疗前与手术治疗后,差异均存在显著性意义,而手术治疗前与手术治疗后相比差异无统计学意义.BGP水平与血清促甲状腺激素水平呈负相关,与T3、T4水平负相关.结论 分化型甲状腺癌治疗的患者存在骨代谢异常,这可能与甲状腺激素水平及TSH水平有关.

abstractsObjective To investigation serum osteocalcin(BGP)levels in patients with differentiated thyroid cancer(DTC)at different stages and relevant influential factors.97 cases with DTC patients'were collected cubital vein before surgery,1 month after surgery(before 131-iodine treatment),1 month after131-iodine treatment and six months after 131-iodine treatment,respectively.T3,T4,TSH,serum osteocalcin(BGP)levels were measured by using of radioimmunoassay.The results showed that:there was a significant difference in the levels of BGP at different times(F=4497.58,P=0.000).Results It at six months after 131-iodine treatment was higher significantly than that at the other time,it at 1 month after 131-iodine treatment higher significantly than that before surgery and after surgery.But there was no significant difference of BGP between before and after surgery.BGP correlated negatively with serum TSH and positively with T3,T4.Conclusion Patients with DTC have abnormal bone metabolism symptoms,which may be related to the level of thyroid hormone and TSH levels.