摘要目的 探讨哮喘儿童缓解期外周血T细胞亚群的意义.方法 采用单克隆抗体间接免疫荧光法检测67例缓解期哮喘儿童(哮喘组)及29例健康儿童(对照组)外周血T细胞亚群的水平.结果 缓解期哮喘儿童与对照组比较,CD3+无明显差异(P＞0.05),CD4+,CD4+/CD8+明显低于对照组(p分别＜0.01,0.05),CD8+明显高于对照组(P＜0.05).结论 哮喘儿童缓解期仍存在T细胞亚群功能紊乱,T细胞亚群功能紊乱在儿童支气管哮喘的发病中发挥一定的作用.

abstractsObjective To investigate significance of T lymphocyte subsets in peripheral blood in the recovery period of children with asthma. Methods To measure CD3 + T cell, CD4 + T cell, CD8 + T cell and CD4 +/CD8 + ratio by indirect immunofluorescence and compare the results. Results The levels of CD4 + T cell,CD4 + /CD8 + ratio in the children with asthma in the recovery period were significantly lower than those in normal subjects(P ＜ 0. 01,0. 05 ); CD8 + was also significantly higher than that in normal subjects (P ＜ 0. 05 ).There were no significant differences in the level of CD3 + between the children with asthma in the recovery period and healthy subjects(P.＞ 0. 05). Conclusion There are imbalances of T cell sebsets in the children with asthma in the recovery period ,The imbalances of T cell sebsets may play an important role in asthma chronic airway inflammation.