摘要目的 观察美罗华(利妥昔单抗,Rituximab)联合COTP方案化疗治疗方案治疗老年弥漫大B细胞性淋巴瘤的临床疗效和毒副反应.方法 13例老年弥漫大B细胞淋巴瘤行RCHOP方案:美罗华375 mg/m2,静脉滴注,每1个周期第1天(d1);环磷酰胺750 mg/m2,静脉注射,d1;表阿霉素60mg/m2,静脉注射,dl;长春新碱1.4 mg/m2,静脉注射,d1;强的松100 mg,口服,d1～d5每21 d为1个周期,重复治疗.全部13例患者完成6个周期化疗后进行疗效评价,随访观察生存情况.结果 总有效率(CR+PR)84.6%(11/13),1年PFS率为76.9%(10/13),1年总生存率为92.3%(12/13).结论 美罗华联合CHOP(RCHOP)方案治疗老年弥漫大B细胞淋巴瘤安全、有效.

abstractsObjective To evaluate the efficacy and toxicity of combination chemotherapy consisting of Rituximab and CHOP(R-CHOP)in elderly patients with diffuse large B-cell lymphoma. Methods 13 patients with elderly patients with diffuse large B-cell lymphoma treated with the Rituximab and CHOP(R-CHOP) regimen. R-CHOP regimen:Rituximab 375 mg/m2 was infused on the first day, Cyclophosphamide 750 mg/m2 Ⅳ,Vincristine 1.4 mg/m2 Ⅳ, and Epirubicin 60 mg/m2 Ⅳ were administered on the first day of the chemotherapy course;Prednisone 100 mg was administered orally from the first day to the fifth day;the cycle was repeated every 21 days. All of the patients have received at least 6 chemotherapy cycles. The therapeutic effect was assessed. All patients were followed up. Results Overall response rate were 84.6%, The 1-year progression free and overall survial rates were 76.9% and 92.3%. Conclusion Combination chemotherapy including Rituximab and CHOP(R-CHOP) is effective and safety in treatment for elderly patients with diffuse large B-cell lymphoma.