摘要目的 评估新辅助化疗联合高-低氧吸入放射治疗浸润性膀胱癌的疗效及安全性.方法 对31例无法耐受或拒绝接受膀胱全切手术的浸润性膀胱癌患者进行保留膀胱治疗,先给予新辅助化疗2周期,然后给予盆腔适形放疗,放疗过程中先后吸入高低浓度氧.对肿瘤部分缓解及复发患者行保留膀胱的手术.结果 肿瘤完全缓解率为71.0%(22/31),部分缓解率29.0%(9/31).9例部分缓解的患者接受了保留膀胱的手术治疗,4例复发患者接受了再次手术治疗.结论 新辅助化疗联合高-低氧吸入放疗为部分无法耐受或拒绝接受膀胱全切术的浸润性膀胱癌患者提供了一种有效的治疗方法.

abstractsObjective To study the efficacy of neoadjuvant chemotherapy plus radiotherapy with inspiring high and low concentration oxygen respectively in invasive bladder cancer. Methods All 31 patients with invasive bladder cancer underwent bladder sparing treatment, who rejected or could not bear total cystectomy.The neoadjuvant treatment protocol consisted of chemotherapy two cycles and radiotherapy with inspiring high and low concentration oxygen respectively. Those patients who obtained partial response or recurred in the follow-up period were treated with bladder sparing operation. Results After neoadjuvant therapy, 22 patients (71.0 %) showed a complete response (CR) and 9 patients (29.0 %) showed a partial response (PR). Total nine patients accepted extensive transurethral resection or partial cystectomy, one of four cases accepted the second operation due to local recurrence. Conclusion Neoadjuvant chemotherapy and radiotherapy with inspiring high and low concentration oxygen respectively is an effective method for partial patients with invasive bladder cancer, especially for those who can not tolerate burden or reject total cystectomy.