摘要目的 观察强直性脊柱炎(ankylosingsp ondyiltis,AS)患者的铁蛋白的变化及其与病情活动指标的相关性.方法 检测40例活动期AS患者铁蛋白、各活动性指标(ESR、CRP)及免疫球蛋白(IgA、IgG、IgM),另设正常对照组30例并检测上述指标;分析40例活动期AS患者铁蛋白与活动性指标的相关性.结果 ①与正常对照组相比,活动期AS患者铁蛋白、ESR、CRP、IgG、IgA明显增高(P<0.05或P<0.01),而IgM无统计学意义(P>0.05);②铁蛋白与ESR、CRP明显正相关(P<0.05或P<0.01),与IgA、IgG、IgM无明显相关性(P>0.05).结论 活动期AS患者出现了铁蛋白、IgA、IgG的升高,且铁蛋白的升高与ESR、CRP具有相关性,IgA、IgG的升高提示活动期AS患者存在免疫紊乱,提示铁蛋白可以作为反应AS疾病活动性的一项客观指标,其升高机制可能是由于炎症因子的释放导致的免疫紊乱.

abstractsObjective To observe the ankylosing spondylitis (ankylosing spondyiltis, AS) in patients with ferritin and its relationship with disease activity indicators of relevance. Methods 40 cases of active AS patients with ferritin, the activity indexs(ESR, CRP) and immunoglobulins (IgA, IgG, IgM), a separate control group of 30 patients and to detect those targets; analysis of 40 cases of active stage AS in patients with ferritin and its relationship with disease activity indicators of relevance. Results ① Compared with normal control group,with active AS patients with ferritin, ESR, CRP, IgG, IgA was significantly higher (P<0.05 or P<0.01),while IgM was not statistically significant (P ＞ 0.05). ② Ferritin and ESR, CRP was positively correlated (P<0.05 or P<0.01),and IgA,IgG,IgM was no significant correlation (P ＞ 0.05). Conclusion AS patients with active stage of the ferritin, IgA, IgG increased, the elevated ferritin and with ESR, CRP are relevant, IgA,IgG elevated in active AS patients have prompted the immune disorder, suggesting that ferritin AS disease activity can serve as a reaction of an objective index, mechanism of the increase may be due to the release of inflammatory factors cause the immune disorder.