摘要目的 探讨急性脑梗死患者颈总动脉平均内膜中层厚度(IMT)与血清高迁移率蛋白-1(HMGB1)的含量变化,及其在急性脑梗死发生过程中的作用和意义.方法 采用高分辨率彩色超声诊断仪测量颈动脉IMT,并采用酶联免疫法测定其血清HMGB1水平,并与60例年龄和性别相当的健康体检者(对照组)进行比较.结果 急性脑梗死患者颈动脉IMT和血清HMGB-1含量较两对照组显著升高;且IMT和血清HMGB1含量之间存在相关性(r=0.64,P＜0.01).结论 监测患者颈动脉IMT和血清HMGB1含量变化有助于预测脑梗死的发生.

abstractsObjective To investigate the relationship between the intima-media thickness (IMT)of common carotidartery and the serum level of HMGB1 in patients with cerebral infarction.Methods The IMT of carotidartery were assessed by high resolution Doppler ultrasonography in 104 patients with with cerebral infarction and 60 healthy controls,and the serum HMGB1 was measured using ELISA,compared with those in 60 healthy subjects.Results The levels of the intima-media thickness (IMT) of common carotidartery and serum HMGB1 of patients with cerebral infarction were markedly higher than those in the control groups.There was an obvious relationship between the intima-media thickness (IMT) of common carotidartery and the level of serum HMGB1 (r = 0.64 ,P ＜ 0.01).Conclusion The level of serum HMGB1 and the intima-media thickness(IMT)of common carotidartery had instructive significance in acute cerebral infarction treating and prognosis estimating.